Профессиональные интересы/научные проекты:
Функционирование и особенности организации убиквитин-протесомной системы, её роль в патогенезе социально-значимых и аутоиммунных заболеваний.
Основные публикации:
1. Kudriaeva AA, Livneh I, Baranov MS, Ziganshin RH, Tupikin AE, Zaitseva SO, Kabilov MR, Ciechanover A, Belogurov AA Jr. In-depth characterization of ubiquitin turnover in mammalian cells by fluorescence tracking. Cell Chem Biol. 2021 Aug 19;28(8):1192-1205.e9. doi: 10.1016/j.chembiol.2021.02.009. Epub 2021 Mar 5. PMID: 33675681.
2. Kudriaeva AA, Saratov GA, Kaminskaya AN, Vladimirov VI, Barzilovich PY, Belogurov AA Jr. Polyamines Counteract Carbonate-Driven Proteasome Stalling in Alkaline Conditions. Biomolecules. 2020 Nov 24;10(12):1597. doi: 10.3390/biom10121597. PMID: 33255475; PMCID: PMC7760842.
3. Mamedov A, Vorobyeva N, Filimonova I, Zakharova M, Kiselev I, Bashinskaya V, Baulina N, Boyko A, Favorov A, Kulakova O, Ziganshin R, Smirnov I, Poroshina A, Shilovskiy I, Khaitov M, Sykulev Y, Favorova O, Vlassov V, Gabibov A, Belogurov A Jr. Protective Allele for Multiple Sclerosis HLA-DRB1*01:01 Provides Kinetic Discrimination of Myelin and Exogenous Antigenic Peptides. Front Immunol. 2020 Jan 17;10:3088. doi: 10.3389/fimmu.2019.03088. PMID: 32010139; PMCID: PMC6978714.
4. Kudriaeva A, Kuzina ES, Zubenko O, Smirnov IV, Belogurov A Jr. Charge-mediated proteasome targeting. FASEB J. 2019 Jun;33(6):6852-6866. doi: 10.1096/fj.201802237R. Epub 2019 Feb 27. PMID: 30811957.
5. Belogurov A Jr, Zakharov K, Lomakin Y, Surkov K, Avtushenko S, Kruglyakov P, Smirnov I, Makshakov G, Lockshin C, Gregoriadis G, Genkin D, Gabibov A, Evdoshenko E. CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study. Neurotherapeutics. 2016 Oct;13(4):895-904. doi: 10.1007/s13311-016-0448-0. PMID: 27324388; PMCID: PMC5081122.
6. Belogurov A Jr, Kuzina E, Kudriaeva A, Kononikhin A, Kovalchuk S, Surina Y, Smirnov I, Lomakin Y, Bacheva A, Stepanov A, Karpova Y, Lyupina Y, Kharybin O, Melamed D, Ponomarenko N, Sharova N, Nikolaev E, Gabibov A. Ubiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunity. FASEB J. 2015 May;29(5):1901-13. doi: 10.1096/fj.14-259333. Epub 2015 Jan 29. PMID: 25634956; PMCID: PMC4415016.
7. Belogurov A Jr, Kudriaeva A, Kuzina E, Smirnov I, Bobik T, Ponomarenko N, Kravtsova-Ivantsiv Y, Ciechanover A, Gabibov A. Multiple sclerosis autoantigen myelin basic protein escapes control by ubiquitination during proteasomal degradation. J Biol Chem. 2014 Jun 20;289(25):17758-66. doi: 10.1074/jbc.M113.544247. Epub 2014 Apr 16. PMID: 24739384; PMCID: PMC4067209.
2. Kudriaeva AA, Saratov GA, Kaminskaya AN, Vladimirov VI, Barzilovich PY, Belogurov AA Jr. Polyamines Counteract Carbonate-Driven Proteasome Stalling in Alkaline Conditions. Biomolecules. 2020 Nov 24;10(12):1597. doi: 10.3390/biom10121597. PMID: 33255475; PMCID: PMC7760842.
3. Mamedov A, Vorobyeva N, Filimonova I, Zakharova M, Kiselev I, Bashinskaya V, Baulina N, Boyko A, Favorov A, Kulakova O, Ziganshin R, Smirnov I, Poroshina A, Shilovskiy I, Khaitov M, Sykulev Y, Favorova O, Vlassov V, Gabibov A, Belogurov A Jr. Protective Allele for Multiple Sclerosis HLA-DRB1*01:01 Provides Kinetic Discrimination of Myelin and Exogenous Antigenic Peptides. Front Immunol. 2020 Jan 17;10:3088. doi: 10.3389/fimmu.2019.03088. PMID: 32010139; PMCID: PMC6978714.
4. Kudriaeva A, Kuzina ES, Zubenko O, Smirnov IV, Belogurov A Jr. Charge-mediated proteasome targeting. FASEB J. 2019 Jun;33(6):6852-6866. doi: 10.1096/fj.201802237R. Epub 2019 Feb 27. PMID: 30811957.
5. Belogurov A Jr, Zakharov K, Lomakin Y, Surkov K, Avtushenko S, Kruglyakov P, Smirnov I, Makshakov G, Lockshin C, Gregoriadis G, Genkin D, Gabibov A, Evdoshenko E. CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study. Neurotherapeutics. 2016 Oct;13(4):895-904. doi: 10.1007/s13311-016-0448-0. PMID: 27324388; PMCID: PMC5081122.
6. Belogurov A Jr, Kuzina E, Kudriaeva A, Kononikhin A, Kovalchuk S, Surina Y, Smirnov I, Lomakin Y, Bacheva A, Stepanov A, Karpova Y, Lyupina Y, Kharybin O, Melamed D, Ponomarenko N, Sharova N, Nikolaev E, Gabibov A. Ubiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunity. FASEB J. 2015 May;29(5):1901-13. doi: 10.1096/fj.14-259333. Epub 2015 Jan 29. PMID: 25634956; PMCID: PMC4415016.
7. Belogurov A Jr, Kudriaeva A, Kuzina E, Smirnov I, Bobik T, Ponomarenko N, Kravtsova-Ivantsiv Y, Ciechanover A, Gabibov A. Multiple sclerosis autoantigen myelin basic protein escapes control by ubiquitination during proteasomal degradation. J Biol Chem. 2014 Jun 20;289(25):17758-66. doi: 10.1074/jbc.M113.544247. Epub 2014 Apr 16. PMID: 24739384; PMCID: PMC4067209.
SPIN РИНЦ:
6221-4405
Researcher ID:
L-5859-2017
Scopus Author ID:
11739436600
ORCID:
0000-0002-2033-9621
Индекс Хирша:
17