Лаборатория биохимических исследований канцерогенеза

Функционирование лаборатории нацелено на получение новых знаний о возникновении и развитии агрессивных опухолей, а также на поиск путей максимально эффективного предотвращения данных процессов.

В лаборатории проводят междисциплинарные исследования на стыке молекулярной и клеточной биологии, биофизики, биомедицины, нанобиотехнологий, направленные на фундаментальное изучение процессов канцерогенеза на молекулярном (молекулярно-генетическом), клеточном, органо-тканевом уровнях и на уровне целого организма.

О лаборатории

Ключевые показатели

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Исследования мирового уровня

Руководитель лаборатории – автор научных публикаций в рецензируемых изданиях мирового уровня, в том числе в Nature Biotechnology IF 54.908, Nature Nanotechnology IF 39.213, Nature Biomedical Engineering IF 25.671, Light: Science & Applications 17.782, ACS Nano IF 15.881, Small IF 13.281, Chemical Engineering Journal IF 13.273, PNAS IF 12.779.
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Цитируемость научных исследований
Более 1000 цитирований наших опубликованных исследований в ведущих мировых изданиях.
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Поддержка молодых специалистов
Работа со студентами и аспирантами, обучение методам, материальная поддержка, содействие в развитии научной карьеры
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Прикладной характер исследований
Цель работы лаборатории – изучить не только фундаментальные характеристики онкологических процессов, но и разработать реальные средства диагностики и онкотерапии.

Наши компетенции и навыки

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Комплексные междисциплинарные исследования
Исследования на стыке молекулярной и клеточной биологии, генной инженерии, физики, химии, биотехнологии и нанотехнологий.
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Работа с живыми объектами
Исследования с использованием бактерий, эукариотических клеток, органоидов, лабораторных грызунов.
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Развитие научной коммуникации
Сотрудничество с академическими институтами – ИОФ РАН, ИБХ РАН; образовательными учреждениями – НИЯУ МИФИ, научно-технологическим университетом «Сириус»; с ООО АБИСЕНС – российским производителем научного оборудования.
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Педагогика и популяризация науки
Образовательная деятельность в ведущих вузах, в т.ч. МФТИ, РГАУ-МСХА, Университет Сириус; активное освещение результатов научной деятельности.
Команда лаборатории
  • Вера Коваленко
  • Федор Завалко
  • Екатерина Терешина

Основные направления сотрудничества

Консультации

Консультации по in vitro и и in vivo исследованиям, сопровождение проектов.

Проведение исследований

Проведение in vitro и и in vivo исследований всех направлений, связанных с деятельностью лаборатории, на высоком методологическом уровне. Проведение доклинических исследований.

Организация мероприятий

Разработка лекционных курсов, проведение школ, мастер-классов, обучающих экспериментов.
Наши партнеры
Основные публикации:
  1. Nikitin, M. P., Shipunova, V. O., Deyev, S. M., & Nikitin, P. I. (2014). Biocomputing based on particle disassembly. Nature Nanotechnology, 9(9), 716-722. IF 40.523 . Q1.
  2. Nikitin, M. P., Zelepukin, I. V., Shipunova, V. O., Sokolov, I. L., Deyev, S. M., & Nikitin, P. I. (2020). Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes. Nature Biomedical Engineering, 4(7), 717-731. IF 29.234. Q1.
  3. Mitiouchkina, T., Mishin, A. S., Somermeyer, L. G., Markina, N. M., Chepurnyh, T. V., Guglya, E. B., ... & Sarkisyan, K. S. (2020). Plants with genetically encoded autoluminescence. Nature Biotechnology, 38(8), 944-946. IF 68.164. Q1.
  4. Shramova, E. I., Chumakov, S. P., Shipunova, V. O., Ryabova, A. V., Telegin, G. B., Kabashin, A. V., ... & Proshkina, G. M. (2022). Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors. Light: Science & Applications, 11(1), 1-13. IF 20.257. Q1.
  5. Kabashin, A. V., Kravets, V. G., Wu, F., Imaizumi, S., Shipunova, V. O., Deyev, S. M., & Grigorenko, A. N. (2019). Phase‐Responsive Fourier Nanotransducers for Probing 2D Materials and Functional Interfaces. Advanced Functional Materials, 29(26), 1902692. IF 19.924. Q1.
  6. Shipunova, V. O., Komedchikova, E. N., Kotelnikova, P. A., Zelepukin, I. V., Schulga, A. A., Proshkina, G. M., ... & Deyev, S. M. (2020). Dual regioselective targeting the same receptor in nanoparticle-mediated combination immuno/chemotherapy for enhanced image-guided cancer treatment. ACS Nano, 14(10), 12781-12795. IF 18.027. Q1.
  7. Zelepukin, I. V., Mashkovich, E. A., Lipey, N. A., Popov, A. A., Shipunova, V. O., Griaznova, O. Y., ... & Zvyagin, A. V. (2022). Direct photoacoustic measurement of silicon nanoparticle degradation promoted by a polymer coating. Chemical Engineering Journal, 430, 132860. IF 16.744. Q1.
  8. Ukrainskaya, V., Rubtsov, Y., Pershin, D., Podoplelova, N., Terekhov, S., Yaroshevich, I., ... & Lerner, R. (2021). Antigen‐Specific Stimulation and Expansion of CAR‐T Cells Using Membrane Vesicles as Target Cell Surrogates. Small, 17(45), 2102643. IF 15.153. Q1.
  9. A.V. Stepanov*, R.S. Kalinin*, V.O. Shipunova*, D. Zhang, J. Xie, Y.P. Rubtsov, V.M. Ukrainskaya, A. Schulga, El.V. Konovalova, D.V. Volkov, I.A. Yaroshevich, A.M. Moysenovich, A.A. Belogurov Jr., H.i Zhang, G.B. Telegin, A.S. Chernov, M.A. Maschan, S.S. Terekhov, P. Wu, S.M. Deyev, R.A. Lerner, A.G. Gabibov, and S.Altman. Switchable targeting of solid tumors by BsCAR T cells. PNAS. 2022, 119, e2210562119. IF 12.779. Q1. *- равный вклад авторов
  10. Shipunova, V. O., Zelepukin, I. V., Stremovskiy, O. A., Nikitin, M. P., Care, A., Sunna, A., ... & Deyev, S. M. (2018). Versatile platform for nanoparticle surface bioengineering based on SiO2-binding peptide and proteinaceous barnase* barstar interface. ACS Applied Materials & Interfaces, 10(20), 17437-17447. IF 10.383. Q1.
  11. Zelepukin, I. V., Popov, A. A., Shipunova, V. O., Tikhonowski, G. V., Mirkasymov, A. B., Popova-Kuznetsova, E. A., ... & Deyev, S. M. (2021). Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics. Materials Science & Engineering: C, 120, 111717. IF 8.457. Q1.
  12. Zelepukin, I. V., Yaremenko, A. V., Shipunova, V. O., Babenyshev, A. V., Balalaeva, I. V., Nikitin, P. I., ... & Nikitin, M. P. (2019). Nanoparticle-based drug delivery via RBC-hitchhiking for the inhibition of lung metastases growth. Nanoscale, 11(4), 1636-1646. IF 8.307. Q1.
  13. Shipunova, V. O., Nikitin, M. P., Nikitin, P. I., & Deyev, S. M. (2016). MPQ-cytometry: a magnetism-based method for quantification of nanoparticle–cell interactions. Nanoscale, 8(25), 12764-12772. IF 8.307. Q1.
  14. Yashchenok, A. M., Gusliakova, O. I., Konovalova, E. V., Novoselova, M. V., Shipunova, V. O., Abakumova, T. O., ... & Deyev, S. M. (2021). Barnase encapsulation into submicron porous CaCO 3 particles: studies of loading and enzyme activity. Journal of Materials Chemistry B, 9(42), 8823-8831. IF 7.571. Q2.
  15. Shramova, E., Proshkina, G., Shipunova, V., Ryabova, A., Kamyshinsky, R., Konevega, A., ... & Deyev, S. (2020). Dual targeting of cancer cells with DARPin-based toxins for overcoming tumor escape. Cancers, 12(10), 3014. IF 6.575. Q1.
  16. Proshkina, G. M., Shramova, E. I., Shilova, M. V., Zelepukin, I. V., Shipunova, V. O., Ryabova, A. V., ... & Kotlyar, A. B. (2021). DARPin_9-29-Targeted Gold Nanorods Selectively Suppress HER2-Positive Tumor Growth in Mice. Cancers, 13(20), 5235. IF 6.575. Q1.
  17. Artykov, A. A., Belov, D. A., Shipunova, V. O., Trushina, D. B., Deyev, S. M., Dolgikh, D. A., ... & Gasparian, M. E. (2020). Chemotherapeutic agents sensitize resistant cancer cells to the DR5-specific variant DR5-B more efficiently than to TRAIL by modulating the surface expression of death and decoy receptors. Cancers, 12(5), 1129. IF 6.575. Q1.
  18. Shipunova, V. O., Kovalenko, V. L., Kotelnikova, P. A., Sogomonyan, A. S., Shilova, O. N., Komedchikova, E. N., ... & Deyev, S. M. (2021). Targeting Cancer Cell Tight Junctions Enhances PLGA-Based Photothermal Sensitizers’ Performance In Vitro and In Vivo. Pharmaceutics, 14(1), 43. IF 6.525. Q1.
  19. Shipunova, V. O., Belova, M. M., Kotelnikova, P. A., Shilova, O. N., Mirkasymov, A. B., Danilova, N. V., ... & Nikitin, M. P. (2022). Photothermal Therapy with HER2-Targeted Silver Nanoparticles Leading to Cancer Remission. Pharmaceutics, 14(5), 1013. IF 6.525. Q1.
  20. Obozina, A. S., Komedchikova, E. N., Kolesnikova, O. A., Iureva, A. M., Kovalenko, V. L., Zavalko, F. A., ... & Shipunova, V. O. (2023). Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics, 15(1), 231. IF 6.525. Q1.
  21. Kovalenko, V. L., Komedchikova, E. N., Sogomonyan, A. S., Tereshina, E. D., Kolesnikova, O. A., Mirkasymov, A. B., ... & Shipunova, V. O. (2023). Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics, 15(1), 92. IF 6.525. Q1.
  22. Komedchikova, E. N., Kolesnikova, O. A., Tereshina, E. D., Kotelnikova, P. A., Sogomonyan, A. S., Stepanov, A. V., ... & Shipunova, V. O. (2023). Two-Step Targeted Drug Delivery via Proteinaceous Barnase-Barstar Interface and Doxorubicin-Loaded Nano-PLGA Outperforms One-Step Strategy for Targeted Delivery to HER2-Overexpressing Cells. Pharmaceutics, 15(1), 52. IF 6.525. Q1.
  23. Drozdov, A. S., Komarova, K. S., Mochalova, E. N., Komedchikova, E. N., Shipunova, V. O., & Nikitin, M. P. (2023). Fluorescent Magnetic Nanoparticles for Bioimaging through Biomimetic Surface Modification. International Journal of Molecular Sciences, 24(1), 134. IF 6.208. Q1.
  24. Shipunova, V. O., Sogomonyan, A. S., Zelepukin, I. V., Nikitin, M. P., & Deyev, S. M. (2021). PLGA Nanoparticles decorated with anti-HER2 affibody for targeted delivery and photoinduced cell death. Molecules, 26(13), 3955. IF 4.927. Q2.
  25. Shipunova, V. O., Kolesnikova, O. A., Kotelnikova, P. A., Soloviev, V. D., Popov, A. A., Proshkina, G. M., ... & Deyev, S. M. (2021). Comparative evaluation of engineered polypeptide scaffolds in HER2-targeting magnetic nanocarrier delivery. ACS Omega, 6(24), 16000-16008. IF 4.132. Q2.
  26. Shipunova, V. O., Nikitin, M. P., Belova, M. M., & Deyev, S. M. (2021). Label-free methods of multiparametric surface plasmon resonance and MPQ-cytometry for quantitative real-time measurements of targeted magnetic nanoparticles complexation with living cancer cells. Materials Today Communications, 29, 102978. IF 3.662. Q2.
  27. Shipunova, V. O., Kotelnikova, P. A., Aghayeva, U. F., Stremovskiy, O. A., Novikov, I. A., Schulga, A. A., ... & Deyev, S. M. (2019). Self-assembling nanoparticles biofunctionalized with magnetite-binding protein for the targeted delivery to HER2/neu overexpressing cancer cells. Journal of Magnetism and Magnetic Materials, 469, 450-455. IF 3.097. Q2.
  28. Shipunova, V. O., & Deyev, S. M. (2022). Artificial Scaffold Polypeptides As an Efficient Tool for the Targeted Delivery of Nanostructures In Vitro and In Vivo. Acta Naturae, 14(1), 54. IF 2.204. Q4.
  29. Sogomonyan, A. S., Shipunova, V. O., Soloviev, V. D., Larionov, V. I., Kotelnikova, P. A., & Deyev, S. M. (2022). 3D Models of Cellular Spheroids As a Universal Tool for Studying the Cytotoxic Properties of Anticancer Compounds In Vitro. Acta Naturae, 14(1), 92. IF 2.204. Q4.
  30. Belova, M. M., Shipunova, V. O., Kotelnikova, P. A., Babenyshev, A. V., Rogozhin, E. A., Cherednichenko, M. Y., & Deyev, S. M. (2019). “Green” synthesis of cytotoxic silver nanoparticles based on secondary metabolites of Lavandula angustifolia mill. Acta Naturae, 11(2 (41)), 47-53. IF 2.204. Q4.
  31. Zelepukin, I. V., Shipunova, V. O., Mirkasymov, A. B., Nikitin, P. I., Nikitin, M. P., & Deyev, S. M. (2017). Synthesis and characterization of hybrid core-shell Fe3O4/SiO2 nanoparticles for biomedical applications. Acta Naturae, 9(4 (34)). IF 2.204. Q4.
  32. Orlov, A. V., Burenin, A. G., Shipunova, V. O., Lizunova, A. A., Gorshkov, B. G., & Nikitin, P. I. (2014). Development of immunoassays using interferometric real-time registration of their kinetics. Acta Naturae, 6(1 (20)), 85-95. IF 2.204. Q4.
  33. Shipunova, V. O., Shramova, E. I., Schulga, A. A., Shilova, M. V., Deyev, S. M., & Proshkina, G. M. (2020). Delivery of barnase to cells in liposomes functionalized by HER2-specific DARPin module. Russian Journal of Bioorganic Chemistry, 46(6), 1156-1161. IF 1.254. Q4.
  34. Shipunova, V. O., Shilova, O. N., Shramova, E. I., Deyev, S. M., & Proshkina, G. M. (2018). A highly specific substrate for NanoLUC luciferase furimazine is toxic in vitro and in vivo. Russian Journal of Bioorganic Chemistry, 44(2), 225-228. IF 1.254. Q4.
  35. Kotelnikova, P. A., Shipunova, V. O., Aghayeva, U. F., Stremovskiy, O. A., Nikitin, M. P., Novikov, I. A., ... & Petrov, R. V. (2018). Synthesis of magnetic nanoparticles stabilized by magnetite-binding protein for targeted delivery to cancer cells. Doklady Biochemistry and Biophysics (Vol. 481, No. 1, pp. 198-200). IF 0.834. Q4.
  36. Shipunova, V. O., Nikitin, M. P., Zelepukin, I. V., Nikitin, P. I., Deyev, S. M., & Petrov, R. V. (2015, September). A comprehensive study of interactions between lectins and glycoproteins for the development of effective theranostic nanoagents. Doklady Biochemistry and Biophysics (Vol. 464, No. 1, pp. 315-318). IF 0.834. Q4.
  37. Shipunova, V. O., Nikitin, M. P., Lizunova, A. A., Ermakova, M. A., Deyev, S. M., & Petrov, R. V. (2013, September). Polyethyleneimine-coated magnetic nanoparticles for cell labeling and modification. Doklady Biochemistry and Biophysics (Vol. 452, No. 1, pp. 245-247). IF 0.834. Q4.
  38. Novoselova, M., Chernyshev, V., Schulga, A., Konovalova, E., Chuprov-Netochin, R., Abakumova, T., German, S., Shipunova, Vi., Mokrousov, M., Prikhozhdenko, E., Bratashov, D., Nozdriukhin, D., Bogorodskiy, A., Grishin, O., Kosolobov, S., Khlebtsov, B., Inozemtseva, O., Zatsepin, T., Deyev, S., Gorin, D. (2022). Effect of Surface Modification of Multifunctional Nanocomposite Drug Delivery Carriers with DARPin on their Biodistribution in vitro and in vivo. ACS Applied Bio Materials.
  39. Yashchenok, A. M., Chernyshev, V. S., Konovalova, E. V., Kholodenko, R., Tsydenzhapova, E., Shipunova, V. O., ... & Gorin, D. A. (2023). Anti‐CD63‐Oligonucleotide Functionalized Magnetic Beads for the Rapid Isolation of Small Extracellular Vesicles and Detection of EpCAM and HER2 Membrane Receptors using DARPin Probes. Analysis & Sensing, e202200059.
  40. Kotelnikova, P. A., Iureva, A. M., Nikitin, M. P., Zvyagin, A. V., Deyev, S. M., & Shipunova, V. O. (2022). Peroxidase-like activity of silver nanowires and its application for colorimetric detection of the antibiotic chloramphenicol. Talanta Open, 6, 100164.
  41. Kalinin, R., Shipunova, V., Chernikov, I., Volkov, D., Shulga, A., Deyev, S., ... & Gabibov, A. (2021, July). Modular approach to CAR-T regulation based on the barnase-barstar complex for therapy of oncological diseases. In FEBS Open Bio (Vol. 11, pp. 93-93).
  42. Popov, A. A., Zelepukin, I. V., Shipunova, V. O., Tikhonowski, G. V., Popova-Kuznetsova, E. A., Mirkasymov, A. B., ... & Deyev, S. M. (2021, March). Laser-generated titanium nitride nanoparticles for biomedical applications: Synthesis and comprehensive biological study. In Synthesis and Photonics of Nanoscale Materials XVIII (Vol. 11675, p. 116750I).
  43. Shipunova, V. O., Belova, M. M., Kotelnikova, P. A., & Deyev, S. M. (2020, November). Plasmonic silver nanoparticles for theranostics of HER2-positive cancer. In 2020 International Conference Laser Optics (ICLO) (pp. 1-1). IEEE.
  44. Kabashin, A. V., Kravets, V. G., Wu, F., Imaizumi, S., Shipunova, V. O., Deyev, S. M., & Grigorenko, A. N. (2020, March). Fourier nanotransducers for phase-sensitive plasmonic biosensing. In Synthesis and Photonics of Nanoscale Materials XVII (Vol. 11269, p. 112690N).
  45. Shipunova, V., Zelepukin, I., Belova, M., Kotelnikova, P., Komedhikova, E., Soloviev, V., & Deyev, S. (2020). Small but smart: plasmonic nanostructures for oncotheranostics. In Physics, Engineering and Technologies for BioMedicine (pp. 54-56).
  46. Zelepukin, I., Shipunova, V., Nikitin, M., & Deyev, S. (2020). Cytoblockade of mononuclear phagocyte system for boosting nanoparticle efficiency. In Physics, Engineering and Technologies for BioMedicine (pp. 62-63).
  47. Komedchikova, E., Shipunova, V., Babenyshev, A., & Deev, S. (2019, July). PLGA-nanoparticles modified with anti-HER-2 affibody for enhance anti-tumor drug delivery. In FEBS OPEN BIO (Vol. 9, pp. 387-387).
  48. Shipunova, V., Belova, M., Komedchikova, E., Babenyshev, A., & Deyev, S. (2019, July). Green synthesis of silver nanoparticles for the targeted delivery to HER2-overexpressing cancer cells. In FEBS OPEN BIO (Vol. 9, pp. 381-381).
  49. Kotelnikova, P., Shipunova, V., & Deyev, S. (2019, July). Remodelling of biomineralization process in vitro for the development of effective anticancer nanoagents. In FEBS OPEN BIO (Vol. 9, pp. 60-60).
  50. Shipunova, V., Zelepukin, I., Kotelnikova, P., Komedhikova, E., Soloviev, V., & Deyev, S. (2019). Multifunctional nanostructures for oncotheranostics. In Physics, Engineering and Technologies for Biomedicine (pp. 64-65).
  51. Care, A., Shipunova, V. O., Liang, L., Deyev, S. M., Zvyagin, A. V., Bergquist, P. L., & Sunna, A. (2018). A platform technology for the bioconjugation of nanoparticles in cancer theranostics. New Biotechnology, 44(Supplement), S56.
  52. Mironova, K., Koroleva, A., Aparin, I., Shipunova, V., Khochenkov, D., Generalova, A., ... & Khaydukov, E. (2018, July). UV-emitting upconversion nanoparticles for the treatment of estrogen-dependent tumors. In FEBS OPEN BIO (Vol. 8, pp. 274-274).
  53. Zelepukin, I. V., Shipunova, V. O., Mirkasymov, A. B., Nikitin, P. I., Nikitin, M. P., & Deyev, S. M. (2018, June). Synthesis of luminescent magnetic nanoparticles with controllable surface properties. In 2018 International Conference Laser Optics (ICLO) (pp. 576-576). IEEE.
  54. Shramova, E., Proshkina, G., Shipunova, V., Ryabova, A., Shilova, O., & Deyev, S. (2018). Photodynamic destraction of deep-tissue tumors using bioluminescence resonance energy transfer. International Journal on Immunorehabilitation, 20(2), 77-79.
  55. Shipunova, V., Kotelnikova, P., Mirkasymov, A., & Deyev, S. (2018). Magnetic nanoparticles modified with scFv mini-antibodies for HER2/neu-overexpressing cancer cells targeting. International Journal on Immunorehabilitation, 20(2), 73-76.
  56. Shipunova, V., Nikitin, M., & Deyev, S. (2017, September). Self-assembling multifunctional nanostructures for the controlled delivery to cancer cells. In FEBS JOURNAL (Vol. 284, pp. 279-280).
  57. Shipunova, V., Nikitin, M., Nikitin, P., & Deyev, S. (2017). Lectin-modified nanoparticles for cancer cell targeting. In Physics, Engineering and Technologies for Biomedicine (pp. 392-393).
  58. Shipunova, V. O., Nikitin, M. P., Nikitin, P. I., & Deyev, S. M. (2016, June). Lectin-based nanoagents for specific cell labelling and optical visualization. In 2016 International Conference Laser Optics (LO) (pp. S2-37). IEEE.
  59. Shipunova, V. O., Nikitin, M. P., Mironova, K. E., Deyev, S. M., & Nikitin, P. I. (2015, July). Complexes of magnetic nanoparticles and scFv antibodies for targeting and visualizing cancer cells. In 2015 IEEE 15th International Conference on Nanotechnology (IEEE-NANO) (pp. 13-16). IEE
Связь с нами
Почта
viktoriya.
shipunova@phystech.edu
Биофармацевтический корпус МФТИ
г. Долгопрудный, Институтский пер., 9с7, к 613