Кандидат технических наук
Научный руководитель
Казанов Марат
Джамалудинович
Основное место работы:
ИППИ им. А.А.Харкевича РАН, зав. сектором "Прикладная биоинформатика"
Контакты:
mkazanov@gmail.com
Профессиональные интересы/научные проекты:
Изучение мутагенеза в геномах клеток злокачественных опухолей, геномика комменсальных и патогенных бактерий человека, роль протеаз в раке и вирусных
инфекциях.
инфекциях.
Основные публикации:
1) Matveev EV, Ponomarev GV, Kazanov MD. Genome-wide bioinformatics analysis of human protease capacity for proteolytic cleavage of the SARS-CoV-2 spike glycoprotein. Microbiol Spectr. 2024 Feb 6;12(2):e0353023. doi: 10.1128/spectrum.03530-23. Epub 2024 Jan 8. PMID: 38189333; PMCID: PMC10846095.
2) Hibberd MC, Webber DM, Rodionov DA, Henrissat S, Chen RY, Zhou C, Lynn HM, Wang Y, Chang HW, Lee EM, Lelwala-Guruge J, Kazanov MD, Arzamasov AA, Leyn SA, Lombard V, Terrapon N, Henrissat B, Castillo JJ, Couture G, Bacalzo NP Jr, Chen Y, Lebrilla CB, Mostafa I, Das S, Mahfuz M, Barratt MJ, Osterman AL, Ahmed T, Gordon JI. Bioactive glycans in a
microbiome-directed food for children with malnutrition. Nature. 2024 Jan;625(7993):157-165. doi: 10.1038/s41586-023-06838-3. Epub 2023 Dec 13. PMID: 38093016; PMCID: PMC10764277.
3) Hudson KM, Klimczak LJ, Sterling JF, Burkholder AB, Kazanov MD, Saini N, Mieczkowski PA, Gordenin DA. Glycidamide-induced hypermutation in yeast single-stranded DNA reveals a ubiquitous clock-like mutational motif in humans. Nucleic Acids Res. 2023 Sep 22;51(17):9075-9100. doi: 10.1093/nar/gkad611. PMID: 37471042; PMCID: PMC10516655.
4) Ponomarev GV, Fatykhov B, Nazarov VA, Abasov R, Shvarov E, Landik NV, Denisova AA, Chervova AA, Gelfand MS, Kazanov MD. APOBEC mutagenesis is low in most types of non-B DNA structures. iScience. 2022 Jun 6;25(7):104535. doi: 10.1016/j.isci.2022.104535. PMID: 35754742; PMCID: PMC9213766.
5) Chervova A, Fatykhov B, Koblov A, Shvarov E, Preobrazhenskaya J, Vinogradov D, Ponomarev GV, Gelfand MS, Kazanov MD. Analysis of gene expression and mutation data points on contribution of transcription to the mutagenesis by APOBEC enzymes. NAR Cancer. 2021 Jul 2;3(3):zcab025. doi: 10.1093/narcan/zcab025. PMID: 34316712; PMCID: PMC8253550.
6) Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN, Islam SMA, Lopez-Bigas N, Klimczak LJ, McPherson JR, Morganella S, Sabarinathan R, Wheeler DA, Mustonen V; PCAWG Mutational Signatures Working Group; Getz G, Rozen SG, Stratton MR; PCAWG Consortium. The repertoire of
mutational signatures in human cancer. Nature. 2020 Feb;578(7793):94-101. doi: 10.1038/s41586-020-1943-3. Epub 2020 Feb 5. Erratum in: Nature. 2023 Feb;614(7948):E41. PMID: 32025018; PMCID: PMC7054213.
7) ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature. 2020 Feb;578(7793):82-93. doi: 10.1038/s41586-020-1969-6.
Epub 2020 Feb 5. Erratum in: Nature. 2023 Feb;614(7948):E39. PMID: 32025007; PMCID: PMC7025898.
2) Hibberd MC, Webber DM, Rodionov DA, Henrissat S, Chen RY, Zhou C, Lynn HM, Wang Y, Chang HW, Lee EM, Lelwala-Guruge J, Kazanov MD, Arzamasov AA, Leyn SA, Lombard V, Terrapon N, Henrissat B, Castillo JJ, Couture G, Bacalzo NP Jr, Chen Y, Lebrilla CB, Mostafa I, Das S, Mahfuz M, Barratt MJ, Osterman AL, Ahmed T, Gordon JI. Bioactive glycans in a
microbiome-directed food for children with malnutrition. Nature. 2024 Jan;625(7993):157-165. doi: 10.1038/s41586-023-06838-3. Epub 2023 Dec 13. PMID: 38093016; PMCID: PMC10764277.
3) Hudson KM, Klimczak LJ, Sterling JF, Burkholder AB, Kazanov MD, Saini N, Mieczkowski PA, Gordenin DA. Glycidamide-induced hypermutation in yeast single-stranded DNA reveals a ubiquitous clock-like mutational motif in humans. Nucleic Acids Res. 2023 Sep 22;51(17):9075-9100. doi: 10.1093/nar/gkad611. PMID: 37471042; PMCID: PMC10516655.
4) Ponomarev GV, Fatykhov B, Nazarov VA, Abasov R, Shvarov E, Landik NV, Denisova AA, Chervova AA, Gelfand MS, Kazanov MD. APOBEC mutagenesis is low in most types of non-B DNA structures. iScience. 2022 Jun 6;25(7):104535. doi: 10.1016/j.isci.2022.104535. PMID: 35754742; PMCID: PMC9213766.
5) Chervova A, Fatykhov B, Koblov A, Shvarov E, Preobrazhenskaya J, Vinogradov D, Ponomarev GV, Gelfand MS, Kazanov MD. Analysis of gene expression and mutation data points on contribution of transcription to the mutagenesis by APOBEC enzymes. NAR Cancer. 2021 Jul 2;3(3):zcab025. doi: 10.1093/narcan/zcab025. PMID: 34316712; PMCID: PMC8253550.
6) Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN, Islam SMA, Lopez-Bigas N, Klimczak LJ, McPherson JR, Morganella S, Sabarinathan R, Wheeler DA, Mustonen V; PCAWG Mutational Signatures Working Group; Getz G, Rozen SG, Stratton MR; PCAWG Consortium. The repertoire of
mutational signatures in human cancer. Nature. 2020 Feb;578(7793):94-101. doi: 10.1038/s41586-020-1943-3. Epub 2020 Feb 5. Erratum in: Nature. 2023 Feb;614(7948):E41. PMID: 32025018; PMCID: PMC7054213.
7) ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature. 2020 Feb;578(7793):82-93. doi: 10.1038/s41586-020-1969-6.
Epub 2020 Feb 5. Erratum in: Nature. 2023 Feb;614(7948):E39. PMID: 32025007; PMCID: PMC7025898.
SPIN РИНЦ:
991910
Researcher ID:
D-6381-2013
Scopus Author ID:
6506765203
ORCID:
0000-0002-2314-5507
Индекс Хирша:
35