Шварц Антон Маркович

Молекулярные основы развития онкологических и аутоиммунных заболеваний, прежде всего, исследование роли полиморфизмов регуляторных элементов в развитии данных заболеваний, а также роли длинных некодирующих РНК в регуляции экспрессии генов, участвующих в онкогенезе и регуляции иммунного ответа на опухолевые и нормальные клетки организма человека.

Belousov PV, Afanasyeva MA, Gubernatorova EO, Bogolyubova AV, Uvarova AN, Putlyaeva LV, Ramanauskaite EM, Kopylov AT, Demin DE, Tatosyan KA, Ustiugova AS, Prokofjeva MM, Lanshchakov KV, Vanushko VE, Zaretsky AR, Severskaia NV, Dvinskikh NY, Abrosimov AY, Kuprash DV, Schwartz AM. Multi-dimensional immunoproteomics coupled with in vitro recapitulation of oncogenic NRASQ61R identifies diagnostically relevant autoantibody biomarkers in thyroid neoplasia. Cancer Lett. 2019 Dec 28;467:96-106. doi: 10.1016/j.canlet.2019.07.013. Epub 2019 Jul 18. PMID: 31326556.

Schwartz AM, Putlyaeva LV, Covich M, Klepikova AV, Akulich KA, Vorontsov IE, Korneev KV, Dmitriev SE, Polanovsky OL, Sidorenko SP, Kulakovskiy IV, Kuprash DV. Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells. Biochim Biophys Acta. 2016 Oct;1859(10):1259-68. doi: 10.1016/j.bbagrm.2016.07.004. Epub 2016 Jul 14. PMID: 27424222.

Korneev KV, Sviriaeva EN, Mitkin NA, Gorbacheva AM, Uvarova AN, Ustiugova AS, Polanovsky OL, Kulakovskiy IV, Afanasyeva MA, Schwartz AM, Kuprash DV. Minor C allele of the SNP rs7873784 associated with rheumatoid arthritis and type-2 diabetes mellitus binds PU.1 and enhances TLR4 expression. Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165626. doi: 10.1016/j.bbadis.2019.165626. Epub 2019 Nov 28. PMID: 31785408.

Schwartz AM, Demin DE, Vorontsov IE, Kasyanov AS, Putlyaeva LV, Tatosyan KA, Kulakovskiy IV, Kuprash DV. Multiple single nucleotide polymorphisms in the first intron of the IL2RA gene affect transcription factor binding and enhancer activity. Gene. 2017 Feb 20;602:50-56. doi: 10.1016/j.gene.2016.11.032. Epub 2016 Nov 19. PMID: 27876533.

Putlyaeva LV, Demin DE, Uvarova AN, Zinevich LS, Prokofjeva MM, Gazizova GR, Shagimardanova EI, Schwartz AM. PTPN11 Knockdown Prevents Changes in the Expression of Genes Controlling Cell Cycle, Chemotherapy Resistance, and Oncogene-Induced Senescence in Human Thyroid Cells Overexpressing BRAF V600E Oncogenic Protein. Biochemistry (Mosc). 2020 Jan;85(1):108-118. doi: 10.1134/S0006297920010101. PMID: 32079522.

Stasevich EM, Murashko MM, Zinevich LS, Demin DE, Schwartz AM. The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer. Biomedicines. 2021 Jul 30;9(8):921. doi: 10.3390/biomedicines9080921. PMID: 34440124; PMCID: PMC8389562.

Demin DE, Afanasyeva MA, Uvarova AN, Prokofjeva MM, Gorbachova AM, Ustiugova AS, Klepikova AV, Putlyaeva LV, Tatosyan KA, Belousov PV, Schwartz AM. Constitutive Expression of NRAS with Q61R Driver Mutation Activates Processes of Epithelial-Mesenchymal Transition and Leads to Substantial Transcriptome Change of Nthy-ori 3-1 Thyroid Epithelial Cells. Biochemistry (Mosc). 2019 Apr;84(4):416-425. doi: 10.1134/S0006297919040096. PMID: 31228933.