Candidate of Physical and Mathematical Sciences

Scientific supervisor

Alexey Bolshakov

Main place of work:

Laboratory of Molecular Neurobiology

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Professional interests/research projects:

The main direction is molecular biological studies of the CNS function in normal and pathological conditions. In particular, studies of the consequences of convulsive activity, as well as studies of the function of the cholinergic system of the brain and disorders that occur during its degeneration. Studies are carried out using standard methods, including PCR, ELISA, registration of focal potentials in tissue sections and in vivo, the use of adeno-associated viruses. In addition, part of the research is devoted to mathematical modeling of neurotransmitter release processes.
Main publications:
  1. Karan AA, Spivak YS, Gerasimov KA, Suleymanova EM, Volobueva MN, Kvichansky AA, Vinogradova LV, Bolshakov AP. CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex. Mol Neurobiol. 2021 Aug;58(8):4028-4037. doi: 10.1007/s12035-021-02395-w. Epub 2021 Apr 27. PMID: 33907944.
  2. Bolshakov AP, Tret'yakova LV, Kvichansky AA, Gulyaeva NV. Glucocorticoids: Dr. Jekyll and Mr. Hyde of Hippocampal Neuroinflammation. Biochemistry (Mosc). 2021 Feb;86(2):156-167. doi: 10.1134/S0006297921020048. PMID: 33832414.
  3. Dobryakova YV, Stepanichev MY, Markevich VA, Bolshakov AP. Long-term potentiation in the hippocampal CA3 to CA1 synapses may be induced in vivo by activation of septal cholinergic inputs. Int J Neurosci. 2020 Sep 23:1-7. doi: 10.1080/00207454.2020.1822834. Epub ahead of print. PMID: 32916077.
  4. Bolshakov AP, Stepanichev MY, Dobryakova YV, Spivak YS, Markevich VA. Saporin from Saponaria officinalis as a Tool for Experimental Research, Modeling, and Therapy in Neuroscience. Toxins (Basel). 2020 Aug 25;12(9):546. doi: 10.3390/toxins12090546. PMID: 32854372; PMCID: PMC7551693.
  5. Bolshakov AP, Kolleker A, Volkova EP, Valiullina-Rakhmatullina F, Kolosov PM, Rozov A. Overexpression of Calretinin Enhances Short-Term Synaptic Depression. Front Cell Neurosci. 2019 Mar 13;13:91. doi: 10.3389/fncel.2019.00091. PMID: 30930749; PMCID: PMC6425694.
  6. Dobryakova YV, Volobueva MN, Manolova AO, Medvedeva TM, Kvichansky AA, Gulyaeva NV, Markevich VA, Stepanichev MY, Bolshakov AP. Cholinergic Deficit Induced by Central Administration of 192IgG-Saporin Is Associated With Activation of Microglia and Cell Loss in the Dorsal Hippocampus of Rats. Front Neurosci. 2019 Mar 12;13:146. doi: 10.3389/fnins.2019.00146. PMID: 30930730; PMCID: PMC6424051.
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