PhD in Chemistry

Scientific supervisor

Ekaterina Finkina

Main place of work:

Institute of Bioorganic Chemistry. MM. Shemyakin and Yu.A. Ovchinnikov RAS, UC

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Professional interests/research projects:

The main direction of research is related to the study of the structure, properties and mechanisms of action of antimicrobial proteins and peptides, which are the molecular factors of the plant innate immunity system. They have a diverse structural organization and have a wide range of biological activity, due to which they not only effectively protect plants under stress, but also take part in the regulation of their growth and development. Interest in plant antimicrobial proteins and peptides is due not only to their important role in plant physiology, but also to the possibility of using them to create sustainable crops, as well as new antifungal and antitumor drugs. In addition, many of them are food and inhalation allergens that cause the development of allergic reactions of varying severity and can be used in the diagnosis and treatment of allergies.
Currently, Finkina E.I. is the main executor of the RSF 2020-2022 project "Molecular and cellular mechanisms of allergic sensitization".
Main publications:
  1. Finkina EI, Melnikova DN, Bogdanov IV, Ignatova AA, Ovchinnikova TV. Do Lipids Influence Gastrointestinal Processing: A Case Study of Major Soybean Allergen Gly m 4. Membranes. 2021; 11(10):754. Published: 30 September 2021.
  2. Bogdanov IV, Finkina EI, Melnikova DN, Ziganshin RH, Ovchinnikova TV. Investigation of Sensitization Potential of the Soybean Allergen Gly m 4 by Using Caco-2/Immune Cells Co-Culture Model. Nutrients. 2021 Jun 16;13(6):2058. doi: 10.3390/nu13062058. PMID: 34208504.
  3. Finkina EI, Melnikova DN, Bogdanov IV, Matveevskaya NS, Ignatova AA, Toropygin IY, Ovchinnikova TV. Impact of Different Lipid Ligands on the Stability and IgE-Binding Capacity of the Lentil Allergen Len c 3. Biomolecules. 2020 Dec 13;10(12):1668. doi: 10.3390/biom10121668. PMID: 33322094.
  4. Melnikova D, Bogdanov I, Ovchinnikova T, Finkina E. Interaction between the Lentil Lipid Transfer Protein Lc-LTP2 and Its Novel Signal Ligand PI(4,5)P2. Membranes (Basel). 2020 Nov 20;10(11):357. doi: 10.3390/membranes10110357. PMID: 33233540.
  5. Melnikova DN, Bogdanov IV, Ignatova AA, Ovchinnikova TV, Finkina EI. New insights into ligand binding by plant lipid transfer proteins: A case study of the lentil Lc-LTP2. Biochem Biophys Res Commun. 2020 Jul 12;528(1):39-45. doi: 10.1016/j.bbrc.2020.04.139. Epub 2020 May 23. PMID: 32456792.
  6. Akhiyarova GR, Finkina EI, Ovchinnikova TV, Veselov DS, Kudoyarova GR. Role of Pea LTPs and Abscisic Acid in Salt-Stressed Roots. Biomolecules. 2019 Dec 20;10(1):15. doi: 10.3390/biom10010015. PMID: 31877653.
  7. Finkina EI, Melnikova DN, Bogdanov IV, Ovchinnikova TV. Plant Pathogenesis-Related Proteins PR-10 and PR-14 as Components of Innate Immunity System and Ubiquitous Allergens. Curr Med Chem. 2017;24(17):1772-1787. doi: 10.2174/0929867323666161026154111. PMID: 27784212.

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