Professional interests/research projects:
Scientific research based on the use of complex, integrative approaches aimed at characterizing and establishing the role of genetic and epigenetic factors in the pathogenesis of socially significant diseases, in a comprehensive assessment of health status, and assessment of sports potential.
In R&D carried out over the past 5 years, methods of whole genome analysis are actively used: high-density genotyping on the platform of DNA chips (Illumina) with a coverage density of up to 5 million SNPs; genome-wide analysis of DNA methylation on the HumanMethylation450 platform and HumanMethylation Epic BeadChip (Illumina); analysis of genomes and exomes using next generation sequencing (NGS) technology - IonProton, Illumina HiSeq2500.
Main topics of scientific interest: associative genetic studies for the assessment of physical potential; epigenetic research on oncology, analysis of whole exome sequencing data, personalized medicine technologies, population genetics.
Original bioinformatic approaches have been developed for processing and annotating sequencing data obtained using new generation sequencers, high-density DNA chips.
In R&D carried out over the past 5 years, methods of whole genome analysis are actively used: high-density genotyping on the platform of DNA chips (Illumina) with a coverage density of up to 5 million SNPs; genome-wide analysis of DNA methylation on the HumanMethylation450 platform and HumanMethylation Epic BeadChip (Illumina); analysis of genomes and exomes using next generation sequencing (NGS) technology - IonProton, Illumina HiSeq2500.
Main topics of scientific interest: associative genetic studies for the assessment of physical potential; epigenetic research on oncology, analysis of whole exome sequencing data, personalized medicine technologies, population genetics.
Original bioinformatic approaches have been developed for processing and annotating sequencing data obtained using new generation sequencers, high-density DNA chips.
Main publications:
1.Turner DC, Gorski PP, Maasar MF, Seaborne RA, Baumert P, Brown AD, Kitchen MO, Erskine RM, Dos-Remedios I, Voisin S, Eynon N, Sultanov RI, Borisov OV, Larin AK, Semenova EA, Popov DV, Generozov EV, Stewart CE, Drust B, Owens DJ, Ahmetov II, Sharples AP. DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity. Sci Rep. 2020 Sep 21;10(1):15360. doi: 10.1038/s41598-020-72730-z. PMID: 32958812; PMCID: PMC7506549.
2.Seaborne RA, Hughes DC, Turner DC, Owens DJ, Baehr LM, Gorski P, Semenova EA, Borisov OV, Larin AK, Popov DV, Generozov EV, Sutherland H, Ahmetov II, Jarvis JC, Bodine SC, Sharples AP. UBR5 is a novel E3 ubiquitin ligase involved in skeletal muscle hypertrophy and recovery from atrophy. J Physiol. 2019 Jul;597(14):3727-3749. doi: 10.1113/JP278073. Epub 2019 Jun 11. PMID: 31093990.
3.Babalyan K, Sultanov R, Generozov E, Sharova E, Kostryukova E, Larin A, Kanygina A, Govorun V, Arapidi G. LogLoss-BERAF: An ensemble-based machine learning model for constructing highly accurate diagnostic sets of methylation sites accounting for heterogeneity in prostate cancer. PLoS One. 2018 Nov 2;13(11):e0204371. doi: 10.1371/journal.pone.0204371. PMID: 30388122; PMCID: PMC6214495.
4.Livshits MA, Khomyakova E, Evtushenko EG, Lazarev VN, Kulemin NA, Semina SE, Generozov EV, Govorun VM. Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol. Sci Rep. 2015 Nov 30;5:17319. doi: 10.1038/srep17319. Erratum in: Sci Rep. 2016;6:21447. Livshts, Mikhail A [corrected to Livshits, Mikhail A]. PMID: 26616523; PMCID: PMC4663484.
5.Al-Khelaifi F, Yousri NA, Diboun I, Semenova EA, Kostryukova ES, Kulemin NA, Borisov OV, Andryushchenko LB, Larin AK, Generozov EV, Miyamoto-Mikami E, Murakami H, Zempo H, Miyachi M, Takaragawa M, Kumagai H, Naito H, Fuku N, Abraham D, Hingorani A, Donati F, Botrè F, Georgakopoulos C, Suhre K, Ahmetov II, Albagha O, Elrayess MA. Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism. Front Genet. 2020 Jun 16;11:595. doi: 10.3389/fgene.2020.00595. PMID: 32612638; PMCID: PMC7308547.
6.Moreland E, Borisov OV, Semenova EA, Larin AK, Andryushchenko ON, Andryushchenko LB, Generozov EV, Williams AG, Ahmetov II. Polygenic Profile of Elite Strength Athletes. J Strength Cond Res. 2020 Dec 3. doi: 10.1519/JSC.0000000000003901. Epub ahead of print. PMID: 33278272.
7.Guilherme JPLF, Bosnyák E, Semenova EA, Szmodis M, Griff A, Móra Á, Almási G, Trájer E, Udvardy A, Kostryukova ES, Borisov OV, Larin AK, Andryushchenko LB, Akimov EB, Generozov EV, Ahmetov II, Tóth M, Junior AHL. The MCT1 gene Glu490Asp polymorphism (rs1049434) is associated with endurance athlete status, lower blood lactate accumulation and higher maximum oxygen uptake. Biol Sport. 2021 Sep;38(3):465-474. doi: 10.5114/biolsport.2021.101638. Epub 2020 Dec 22. PMID: 34475628; PMCID: PMC8329966.
2.Seaborne RA, Hughes DC, Turner DC, Owens DJ, Baehr LM, Gorski P, Semenova EA, Borisov OV, Larin AK, Popov DV, Generozov EV, Sutherland H, Ahmetov II, Jarvis JC, Bodine SC, Sharples AP. UBR5 is a novel E3 ubiquitin ligase involved in skeletal muscle hypertrophy and recovery from atrophy. J Physiol. 2019 Jul;597(14):3727-3749. doi: 10.1113/JP278073. Epub 2019 Jun 11. PMID: 31093990.
3.Babalyan K, Sultanov R, Generozov E, Sharova E, Kostryukova E, Larin A, Kanygina A, Govorun V, Arapidi G. LogLoss-BERAF: An ensemble-based machine learning model for constructing highly accurate diagnostic sets of methylation sites accounting for heterogeneity in prostate cancer. PLoS One. 2018 Nov 2;13(11):e0204371. doi: 10.1371/journal.pone.0204371. PMID: 30388122; PMCID: PMC6214495.
4.Livshits MA, Khomyakova E, Evtushenko EG, Lazarev VN, Kulemin NA, Semina SE, Generozov EV, Govorun VM. Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol. Sci Rep. 2015 Nov 30;5:17319. doi: 10.1038/srep17319. Erratum in: Sci Rep. 2016;6:21447. Livshts, Mikhail A [corrected to Livshits, Mikhail A]. PMID: 26616523; PMCID: PMC4663484.
5.Al-Khelaifi F, Yousri NA, Diboun I, Semenova EA, Kostryukova ES, Kulemin NA, Borisov OV, Andryushchenko LB, Larin AK, Generozov EV, Miyamoto-Mikami E, Murakami H, Zempo H, Miyachi M, Takaragawa M, Kumagai H, Naito H, Fuku N, Abraham D, Hingorani A, Donati F, Botrè F, Georgakopoulos C, Suhre K, Ahmetov II, Albagha O, Elrayess MA. Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism. Front Genet. 2020 Jun 16;11:595. doi: 10.3389/fgene.2020.00595. PMID: 32612638; PMCID: PMC7308547.
6.Moreland E, Borisov OV, Semenova EA, Larin AK, Andryushchenko ON, Andryushchenko LB, Generozov EV, Williams AG, Ahmetov II. Polygenic Profile of Elite Strength Athletes. J Strength Cond Res. 2020 Dec 3. doi: 10.1519/JSC.0000000000003901. Epub ahead of print. PMID: 33278272.
7.Guilherme JPLF, Bosnyák E, Semenova EA, Szmodis M, Griff A, Móra Á, Almási G, Trájer E, Udvardy A, Kostryukova ES, Borisov OV, Larin AK, Andryushchenko LB, Akimov EB, Generozov EV, Ahmetov II, Tóth M, Junior AHL. The MCT1 gene Glu490Asp polymorphism (rs1049434) is associated with endurance athlete status, lower blood lactate accumulation and higher maximum oxygen uptake. Biol Sport. 2021 Sep;38(3):465-474. doi: 10.5114/biolsport.2021.101638. Epub 2020 Dec 22. PMID: 34475628; PMCID: PMC8329966.
SPIN РИНЦ:
9986-7842
Researcher ID:
U-3431-2017
Scopus Author ID:
57201982531
ORCID:
0000-0002-6314-4883
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11
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