Candidate of Physical and Mathematical Sciences

Scientific supervisor

Nikolai Ilyinsky

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Professional interests/research projects:

Study of dynamics, structure of non-membrane organelles in cells and in vitro. The role of the internal disorder of the structure in the functioning of groups of proteins belonging to a certain biological process. Optogenetics of intracellular processes.
Main publications:
1. Nesterov SV, Ilyinsky NS, Uversky VN. Liquid-liquid phase separation as a common organizing principle of intracellular space and biomembranes providing dynamic adaptive responses. Biochim Biophys Acta Mol Cell Res. 2021 Oct;1868(11):119102. doi: 10.1016/j.bbamcr.2021.119102. Epub 2021 Jul 20. PMID: 34293345.

2. Ilyinsky NS, Nesterov SV, Shestoperova EI, Fonin AV, Uversky VN, Gordeliy VI. On the Role of Normal Aging Processes in the Onset and Pathogenesis of Diseases Associated with the Abnormal Accumulation of Protein Aggregates. Biochemistry (Mosc). 2021 Mar;86(3):275-289. doi: 10.1134/S0006297921030056. PMID: 33838629.

3. Varizhuk A, Ilyinsky N, Smirnov I, Pozmogova G. G4 Aptamers: Trends in Structural Design. Mini Rev Med Chem. 2016;16(16):1321-1329. doi: 10.2174/1389557516666160321114715. PMID: 26996618.

4. Kaluzhny D, Ilyinsky N, Shchekotikhin A, Sinkevich Y, Tsvetkov PO, Tsvetkov V, Veselovsky A, Livshits M, Borisova O, Shtil A, Shchyolkina A. Disordering of human telomeric G-quadruplex with novel antiproliferative anthrathiophenedione. PLoS One.

5. Ilyinsky NS, Shchyolkina AK, Borisova OF, Mamaeva OK, Zvereva MI, Azhibek DM, Livshits MA, Mitkevich VA, Balzarini J, Sinkevich YB, Luzikov YN, Dezhenkova LG, Kolotova ES, Shtil AA, Shchekotikhin AE, Kaluzhny DN. Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties. Eur J Med Chem. 2014 Oct 6;85:605-14. doi: 10.1016/j.ejmech.2014.08.030. Epub 2014 Aug 8. PMID: 25127152.

6. Il'inskiĭ NS, Varizhuk AM, Beniaminov AD, Puzanov MA, Shchelkina AK, Kaliuzhnyĭ DN. [G-quadruplex ligands: mechanisms of anticancer action and target binding]. Mol Biol (Mosk). 2014 Nov-Dec;48(6):891-907. Russian. PMID: 25845230.
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