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Candidate of Biological Sciences
Director of the Phystech School of Biological and Medical Physics

Team

Denis V. Kuzmin

Reception hours:
Monday: 12:00-13:00
Email:
kuzmin.dv@mipt.ru
Write to the mail
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Ru

Education

2017-2019: Moscow School of Management SKOLKOVO. MBA.

2007-2011: M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Laboratory of Structure and Function of Human Genes. Candidate of Biological Sciences, specialty "Molecular Biology".

2002-2007: Lomonosov Moscow State University, specialty "Biochemistry".

Knowledge of languages:

Russian – native

English – fluent

Professional experience:
2016-2019
Viridias LLC (RUSNANO portfolio company). CEO. A biotech startup for the development and introduction into clinical practice of a new generation of antibiotics against methicillin-resistant staphylococcus. The company has successfully attracted funding from the I2BF-Rusnano Strategic Recourses Fund and the Skolkovo Foundation. Within the framework of the Start-Up Village, the Viridias project took second place among all participants of the competition (2017).
2014-2019
LLC "Solixant" (RUSNANO portfolio company). CEO and member of the Board of Directors. Organization of the activities of the Russian division of the American company Solix Ingredients Inc.; implementation of technology transfer in the Russian Federation – import and localization of Solix photobioreactors of the Lumia AGS260 series, which have no analogues in the Russian Federation; organization of screening of microalgae strains from the collection of all leading research institutes for the presence of substances with high potential for commercialization in the field of biologically active additives.
Solixant LLC was successfully allocated into an independent company and attracted funding from the I2BF-Rusnano Strategic Recourses Fund and the Skolkovo Foundation. As part of the activities of Solixant LLC, the Pond Superfoods spin-off project was launched – the production of a biologically active additive based on spirulina. The product was brought to the largest retail and pharmacy chains of the Russian Federation.
2013-2019
Educational and Scientific Center of IBH RAS. Head of the scientific group. Development of antitumor drugs of molecular-directed action based on antimicrobial peptides of animals.
2009-2014

Independent laboratory "INVITRO". Working on a franchise model.

Creation and management of the development of large centers, attraction of investments, financial and strategic planning; bringing to the market statistical data of molecular genetic studies of diagnostics; launch and implementation of federal programs with the Ministry of Health and Social Development.

Main publications:
  1. Xue W., Wang Y., Smirnova A.V., Malakhov P.A., Pustovalova M., Kuzmin D.V., Leonov S. The miR-16-1-3p Suppresses Proliferation and Invasiveness via the MDM2–p53 Axis in TGF-β1 Signaling in Osteosarcoma — Molecular Therapy Oncology, 2026. — 201249. —DOI:10.1016/j.omton.2026.201249
  2. Maksimova K., Pustovalova M., Kuzmin D.V., Leonov S., Merkher Y. Mapping metastatic potential through cytoskeletal remodeling: A mechanobiology-based multi-cancer analysis — Biochemical and Biophysical Research Communications, 2026 Apr. T.808. — 153428. — DOI:10.1016/j.bbrc.2026.153428
  3. Wang Y., Xue W., Sakr N., Pushkarev A.V., Mochalova E.N., Pustovalova M., Kuzmin D.V., Leonov S. A CAM bioimaging model reveals the connection between VEGFA vascular remodeling and enhanced sarcoma progression via tumor secretome — Scientific Reports, 2026 Mar. T.16. №1. — 12525. — DOI:10.1038/s41598-026-42154-2
  4. Xue W., Wang Y., Pugacheva P., Smirnova A., Chuprov-Netochin R., Pustovalova M., Kuzmin D., Leonov S. Loss of miR-16-1-3p Activity Predicts Chemoresistance and Progression in Osteosarcoma: An Integrative Clinicopathologic Study — Research Square, 2025. — DOI:10.21203/rs.3.rs-7665473/v1
  5. Малахов Ф.А., Максимов В.В., Пустовалова М.В., Смирнова А.В., Нофал З., Сабуров В., Осипов А.Н., Кузьмин Д.В., Леонов С.В. Опухоль-супрессирующее и антиметастатическое влияние cверхэкспресии мiR-16-1-3p и miR-16-2-3p на радиорезистентные клетки А549 немелкоклеточного рака легкого — Медицинская радиология и радиационная безопасность. 2025. Т. 70. № 2. С. 27–34 — DOI:10.33266/1024-6177-2025-70-2-27-34
  6. Emelyanova AG, Zolotovskaia MA, Poddubskaya EV, Modestov AA, Prassolov VS, Kuzmin DV, Buzdin AA. Activation of the ERK1/2 Molecular Pathways and Its Relation to the Pathogenicity of Human Malignant Tumors — Acta Naturae. 2025 Jan-Mar;17(1):36-51 — DOI: 10.32607/actanaturae.27497
  7. Wang Y., Xue W., Pustovalova M., Kuzmin D.V., Leonov S. Chick Embryo Chorioallantoic Membrane (CAM) Model for Cancer Studies and Drug Evaluation — FBL, 2025, Т. 30, № 5. — DOI: 10.31083/FBL37456
  8. Sorokin, B., Filimonova, A., Emelianova, A., Kublitski, V., Gvozd, A., Shmygarev, V., Yampolsky, I., Guglya, E., Gusev, E., & Kuzmin, D. Novel Triazeneindole Antibiotics: Synthesis and Hit-to-Lead Optimization — International Journal of Molecular Sciences, 2025, 26(5), 1870 — DOI: 10.3390/ijms26051870
  9. Emelyanova, A., Zolotovskaia, M., Poddubskaya, E. et al. Activation of P38 MAPK Signaling Cascade is Linked with Clinical Outcomes and Therapeutic Responses in Human Cancers — Biochemistry Moscow, 2024, 89, 2155–2173 — DOI: 10.1134/S0006297924120058
  10. Kuzmin D.V. Molecular pathway approach in biotechnology // Molecular Pathway Analysis Using High-Throughput OMICS Molecular Data: Analysis of molecular pathway composition, architecture, and activation using high-throughput genomic, epigenetic, transcriptomic, proteomic, and metabolomic data. (Ed. Buzdin A.A.) – Elsevier, 2024.P. 339–353 — ISBN: 0443155690, 9780443155697
  11. Mekic, R., Zolotovskaia, M. A., Sorokin, M., Mohammad, T., Shaban, N., Musatov, I., Tkachev, V., Modestov, A., Simonov, A., Kuzmin, D., & Buzdin, A. Number of human protein interactions correlates with structural, but not regulatory conservation of the respective genes – Frontiers, 2024, October 14. – DOI: 10.3389/fgene.2024.1472638
  12. Gusev, E. S., N. A., Martynenko, E. S., Podunay, Kuzmin, D. V. Morphology, phylogenetic position and distribution of Mallomonas mangofera and Mallomonas foveata comb. et stat. nov. (Synurales, Chrysophyceae) – Phytotaxa. Magnolia Press, 2024. P. 224–38 — DOI: 10.11646/phytotaxa.662.3.2
  13. Gusev, E. S., Podunay, Y. A., Martynenko, N. A., Tran, H., Kuzmin, D. V. Mallomonas gemina comb. et stat. nov. (Synurales, Chrysophyceae) – a new combination based on molecular studies – Phytotaxa, 2024. Vol. 665. P. 221-232 — DOI: 10.11646/phytotaxa.155.1.6
  14. Boris Sorokin, Evgeniy Gusev, Zorigto Namsaraev, Anna Emelianova, Elena Patova Irina Novakovskaya, Vladimir Vinokurov, Denis Kuzmin. Effect of microalgae feed supplementation on growth performance and feeding efficiency of tilapia fry – Journal of Applied Phycology, 2024 – DOI: 10.1007/s10811-024-03232-y
  15. Rozenberg JM, Sorokin BA, Mukhambetova AN, Emelianova AA, Kuzmin VV, Belogurova-Ovchinnikova OY, Kuzmin DV. Recent advances and fundamentals of microalgae cultivation technology – Biotechnol J. 2024 Mar;19(3):e2300725 – DOI: 10.1002/biot.202300725
  16. Namsaraev Z, Kozlova A, Tuzov F, Krylova A, Izotova A, Makarov I, Bezgreshnov A, Melnikova A, Trofimova A, Kuzmin D, Patrushev M, Toshchakov S. Biogeographic Analysis Suggests Two Types of Planktonic Prokaryote Communities in the Barents Sea – Biology. 2023; 12(10):1310 – DOI: 10.3390/biology12101310
  17. Borisov N, Tkachev V, Simonov A, Sorokin M, Kim E, Kuzmin D, Karademir-Yilmaz B, Buzdin A. Uniformly shaped harmonization combines human transcriptomic data from different platforms while retaining their biological properties and differential gene expression patterns – Front Mol Biosci. 2023 Sep 6;10:1237129 – DOI: 10.3389/fmolb.2023.1237129
  18. Zolotovskaia MA, Modestov AA, Suntsova MV, Rachkova AA, Koroleva EV, Poddubskaya EV, Sekacheva MI, Tkachev VS, Garazha AV, Glusker AA, Seryakov AP, Vladimirova US, Rumiantsev PO, Moisseev AA, Zharkov DO, Kuzmin DV, Zhao X, Prassolov VS, Shegay PV, Li X, Steinbichler TB, Kim E, Sorokin MI, Wang Y, Buzdin AA. Pan-cancer antagonistic inhibition pattern of ATM-driven G2/M checkpoint pathway vs other DNA repair pathways – DNA Repair (Amst). 2023 Mar;123:103448 – DOI: 10.1016/j.dnarep.2023.103448
  19. Rabushko E, Sorokin M, Suntsova M, Seryakov AP, Kuzmin DV, Poddubskaya E, Buzdin AA. Experimentally Deduced Criteria for Detection of Clinically Relevant Fusion 3′ Oncogenes from FFPE Bulk RNA Sequencing Data — Biomedicines. 2022; 10(8):1866 — DOI: 10.3390/biomedicines10081866
  20. Zolotovskaia, M., Kovalenko, M.A., Tkachev, V., Simonov, A., Sorokin, M., Kim, E., Kuzmin, D., Karademir-Yilmaz, B., Buzdin, A.A. Next-Generation Grade and Survival Expression Biomarkers of Human Gliomas Based on Algorithmically Reconstructed Molecular Pathways — International Journal of Molecular Sciences, 2023 (13) — DOI: 10.3390/ijms23137330
  21. Raevskiy, M., Sorokin, M., Zakharova, G., Tkachev, V., Borisov, N., Kuzmin, D., Kremenchutckaya, K., Gudkov, A., Kamashev, D., Buzdin, A. Better Agreement of Human Transcriptomic and Proteomic Cancer Expression Data at the Molecular Pathway Activation Level — International Journal of Molecular Sciences, 2023 (5), art. no. 2611 — DOI: 10.3390/ijms23052611
  22. Zolotovskaia, M.A., Tkachev, V.S., Guryanova, A.A., Simonov, A.M., Raevskiy, M.M., Efimov, V.V., Wang, Y., Sekacheva, M.I., Garazha, A.V., Borisov, N.M., Kuzmin, D.V., Sorokin, M.I., Buzdin, A.A. OncoboxPD: human 51 672 molecular pathways database with tools for activity calculating and visualization — Computational and Structural Biotechnology Journal, 2022, 20, pp. 2280-2291 — DOI: 10.1016/j.csbj.2022.05.006
  23. Sorokin, M., Gorelyshev, A., Efimov, V., Zotova, E., Zolotovskaia, M., Rabushko, E., Kuzmin, D., Seryakov, A., Kamashev, D., Li, X., Poddubskaya, E., Suntsova, M., Buzdin, A. RNA Sequencing Data for FFPE Tumor Blocks Can Be Used for Robust Estimation of Tumor Mutation Burden in Individual Biosamples — Frontiers in Oncology, 2021, 11, art. no. 732644 — DOI: 10.3389/fonc.2021.732644
  24. Sorokin, M., Raevskiy, M., Zottel, A., Šamec, N., Vidmar, M.S., Matjašič, A., Zupan, A., Mlakar, J., Suntsova, M., Kuzmin, D.V., Buzdin, A., Jovčevska, I. Large-scale transcriptomics-driven approach revealed overexpression of crnde as a poor survival prognosis biomarker in glioblastoma — Cancers, 2021, 13 (14), art. no. 3419 — DOI: 10.3390/cancers13143419
  25. Zolotovskaia, M., Tkachev, V., Sorokin, M., Garazha, A., Kim, E., Kantelhardt, S.R., Bikar, S.-E., Zottel, A., Šamec, N., Kuzmin, D., Sprang, B., Moisseev, A., Giese, A., Efimov, V., Jovčevska, I., Buzdin, A. Algorithmically deduced FREM2 molecular pathway is a potent grade and survival biomarker of human gliomas — Cancers, 2021, 13 (16), art. no. 4117 — DOI: 10.3390/cancers13164117
  26. Sorokin M, Borisov N., Kuzmin D, Gudkov A., Zolotovskaia M, Garazha A, Buzdin A. Algorithmic Annotation of Functional Roles for Components of 3,044 Human Molecular Pathways — Frontiers in Genetics, 2021, 12, art. no. 617059 — DOI: 10.3389/fgene.2021.617059
  27. Kamashev, D., Sorokin, M., Kochergina, I., Drobyshev, A., Vladimirova, U., Zolotovskaia, M., Vorotnikov, I., Shaban, N., Raevskiy, M., Kuzmin, D., Buzdin, A. Human blood serum can donor-specifically antagonize effects of EGFR-targeted drugs on squamous carcinoma cell growth — Heliyon, 2021, 7 (3), art. no. e06394 — DOI: 10.1016/j.heliyon.2021.e06394
  28. Sorokin, M., Kholodenko, I., Kalinovsky, D., Shamanskaya, T., Doronin, I., Konovalov, D., Mironov, A., Kuzmin, D., Nikitin, D., Deyev, S., Buzdin, A., Kholodenko, R. RNA sequencing-based identification of ganglioside GD2-positive cancer phenotype — Biomedicines, 2020, 8 (6), art. no. 142 — DOI: 10.3390/biomedicines8060142
  29. Zolotovskaia MA, Tkachev VS, Seryakov AP, Kuzmin DV, Kamashev DE, Sorokin MI, Roumiantsev SA, Buzdin AA. Mutation Enrichment and Transcriptomic Activation Signatures of 419 Molecular Pathways in Cancer — Cancers (Basel). 2020 Jan 22;12(2). pii: E271 — DOI: 10.3390/cancers12020271
  30. Zolotovskaia MA, Sorokin MI, Emelianova AA, Borisov NM, Kuzmin DV, Borger P, Garazha AV, Buzdin AA. Pathway Based Analysis of Mutation Data Is Efficient for Scoring Target Cancer Drugs. — Front Pharmacol, 2019 Jan 23;10:1 — DOI: 10.3389/fphar.2019.00001.
  31. Anna A. Emelianova, Denis V. Kuzmin, Pavel V. Panteleev, Maxim Sorokin, Anton A. Buzdin and Tatiana V. Ovchinnikova. Anticancer Activity of the Goat Antimicrobial Peptide ChMAP-28 — Front Pharmacol. 2018; 9: 1501 — DOI: 10.3389/fphar.2018.01501
  32. Maltsev, Y., Gusev, E., Maltseva, I., Kulikovskiy, M., Namsaraev, Z., Petrushkina, M., Filimonova, A., Sorokin, B., Golubeva, A., Butaeva, G., Khrushchev, A., Zotko, N., Kuzmin, D. Description of a new species of soil algae, Parietochloris grandis sp. nov., and study of its fatty acid profiles under different culturing condition — Algal Research, 2018, 33, pp. 358-368 — DOI: 10.1016/j.algal.2018.06.008
  33. Marggraf MB, Panteleev PV, Emelianova AA, Sorokin MI, Bolosov IA, Buzdin AA, Kuzmin DV, Ovchinnikova TV. Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III — Mar Drugs (2018), 16 (12) — DOI: 10.3390/md16120466
  34. Mamaeva A, Namsaraev Z, Maltsev Y, Gusev E, Kulikovskiy M, Petrushkina M, Filimonova A, Sorokin B, Zotko N, Vinokurov V, Kopitsyn D, Petrova D, Novikov A, and Kuzmin D. Simultaneous increase in cellular content and volumetric concentration of lipids in bracteacoccus bullatus cultivated at reduced nitrogen and phosphorus concentrations — Journal of Applied Phycology, 2018 — DOI: 10.1007/s10811-018-1471-9
  35. Kuzmin DV, Emelianova AA, Kalashnikova MB, Panteleev PV, Ovchinnikova TV. In Vitro Study of Antitumor Effect of Antimicrobial Peptide Tachyplesin I in Combination with Cisplatin I — Bull Exp Biol Med. 2018 June — DOI: 10.1007/s10517-018-4134-6.
  36. Kuzmin DV, Emelianova AA, Kalashnikova MB, Panteleev PV, Balandin SV, Serebrovskaya EO, Belogurova-Ovchinnikova OY, Ovchinnikova TV. Comparative in vitro study on cytotoxicity of recombinant β-hairpin peptides — Chem Biol Drug Des. 2018, Vol 91, Nо 1, pp 294-303 — DOI: 10.1111/cbdd.13081
  37. Sorokin M, Kholodenko R, Grekhova A, Suntsova M, Pustovalova M, Vorobyeva N, Kholodenko I, Malakhova G, Garazha A, Nedoluzhko A, Vasilov R, Poddubskaya E, Kovalchuk O, Adamyan L1, Prassolov V, Allina D, Kuzmin D, Ignatev K, Osipov A, Buzdin A. Acquired resistance to tyrosine kinase inhibitors may be linked with the decreased sensitivity to X-ray irradiation — Oncotarget. 2017 Dec 27;9(4):5111-5124 IF 5.1 — DOI: 10.18632/oncotarget.23700
  38. Kuzmin DV, Emelianova AA, Kalashnikova MB, Panteleev PV, Ovchinnikova TV. Effect of N- and C-terminal modifications on cytotoxic properties of antimicrobial peptide tachyplesin I — Bull Exp Biol Med. 2017 Apr;162(6):754-757 — DOI: 10.1007/s10517-017-3705-2
  39. Petrushkina, M., Gusev, E., Sorokin, B., Zotko, N., Mamaeva, A., Filimonova, A., Kulikovskiy.M., Maltsev E., Yampolsky I., Guglya E., Vinokurov V., Namsaraev Z.,Kuzmin D. Fucoxanthin production by heterokont microalgae — Algal Research.№24.2017. P.387-393 — DOI: 10.1016/j.algal.2017.03.016
  40. Artcibasova AV, Korzinkin MB, Sorokin MI, Shegay PV, Zhavoronkov AA, Gaifullin N, Alekseev BY, Vorobyev NV, Kuzmin DV, Kaprin АD, Borisov NM, Buzdin AA. MiRImpact, a new bioinformatic method using complete microRNA expression profiles to assess their overall influence on the activity of intracellular molecular pathways — Cell Cycle. 2016;15(5):689-98 — DOI: 10.1080/15384101.2016.1147633
  41. Denis V. Kuzmin, Tatyana V. Vinogradova, Eugene P. Kopantzev and Eugene D. Sverdlov. Cre-LoxP Mediated Strong Enhancement of pBIRC5 Promoter Driven Suicide of Cancer Cells with CD/UPRT and Fluorocytosine — The Open Gene Therapy Journal, 2010, 3, 31-39 — DOI: 10.2174/1875037001003010031
  42. Kuzmin D, Gogvadze E, Kholodenko R, Grzela DP, Mityaev M, Vinogradova T, Kopantzev E, Malakhova G, Suntsova M, Sokov D, Ivics Z, Buzdin A. Novel strong tissue specific promoter for gene expression in human germ cells — BMC Biotechnol. 2010 Aug 17;10:58 — DOI: 10.1186/1472-6750-10-58.
  43. D. K. Slizhikova, M. V. Zinovyeva, D. V. Kuzmin, E. V. Snezhkov, M. I. Shakhparonov, R. I. Dmitriev, N.V. Antipova, L. L. Zavalova, E. D. Sverdlov. Decreased expression of the human immunoglobulin J-chain gene in squamous cell cancer and adenocarcinoma of the lungs — Mol Biol (Mosk). 2007 Jul-Aug;41(4):659-65 — DOI: 10.1134/S0026893307040115
  44. Alekseenko I.V., Kuzmin, D.V., Pleshkan, V.V., Zinovyeva, M.V., Sverdlov E.D. Cytotoxicities of cytosine deaminase and herpes simplex virus thymidine kinase genes in melanoma cells are not affected by the promoter strength — Russian Journal of Bioorganic Chemistry. 2013, 39 (6): 745-748 — DOI: 10.1134/S1068162013060010
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