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Laboratory of Molecular Medical Diagnostics

In the laboratory of molecular medical diagnostics, together with the laboratory of ionic and molecular physics, research is being carried out in the field of the development of mass spectrometry methods and their application to the study of biological systems. The laboratory team is engaged in both fundamental research on the physical foundations of mass spectrometry (processes that accompany ionization, fragmentation, and detection of ions) and the development of applications of mass spectrometry in medicine and biology. The area of scientific interests, in addition to the technologies of mass spectrometric study of biomolecules, includes such areas of life sciences as proteomics, metabolomics, and lipidomics.

About Laboratory

En

Ru

1

Study of biological objects

Study of biological objects based on

ultra-high resolution mass spectrometry, including

including for the identification of toxins, pathological

body conditions

2

Technology improvement

Mass spectrometric analysis improvement:
development of new ion sources, development of new
approaches to signal detection, modeling
movement of ions in complex electromagnetic fields,
application of machine learning methods for
interpretation of complex data

Igor Popov
Head of Laboratory, Ph.D.

Projects

Mass spectrometry in neurosurgery

In cooperation with the Center for Neurosurgery named after Academician N.N. Burdenko, work is underway in the laboratory aimed at developing molecular neuronavigation systems and expanding the capabilities of pathomorphological laboratories. In order to improve approaches to intraoperative examination of brain tissues, methods of molecular profiling and direct mass spectrometry are being actively developed. The bioinformatics group of the IMP laboratory is leading a project to develop approaches to processing molecular profiling data and classification analysis, including using machine learning technologies and big data analysis

Study of molecular processes accompanying non-generative diseases

The laboratory conducts work on the study of pathogenesis and the development of methods for the early diagnosis of neurodegenerative diseases. The project aims to create new methods for the early diagnosis of Alzheimer's disease (AD) and mild cognitive decline (MCI), as well as to elucidate the role of specific physiological and molecular processes in the development of AD and MCI. The role of various isoforms and post-translational modifications of the beta-amyloid peptide, whose accumulation is one of the objective manifestations of Alzheimer's disease, is being studied. To do this, the laboratory develops special methods of mass spectrometric analysis, which are characterized by high sensitivity and rapidity. The characteristic site-dependent modifications of plasma proteins in patients with Alzheimer's disease and MCI are being identified. The role of platelets in the formation of neurotoxic forms of beta-amyloid and isoforms of various proteins associated with neurodegenerative diseases is being studied.

Direct methods of mass spectrometry

In collaboration with the group of Professor J. Shia from the University. Sun Yat Sen (Taiwan) is implementing a project related to the development of direct mass spectrometry approaches for the rapid detection of drugs, toxins and their metabolites on the skin and in human biological fluids. Research is underway on the fundamental processes that accompany ionization and the behavior of ions in electrostatic fields, aimed at improving the methods of sampling and direct ionization of analytes in order to create a rapid diagnostic tool for practical use, or a laboratory method for use in medical research

Detection of viral lesions of plants

The great genetic diversity of plant viruses and the similarity of pathological manifestations that accompany viral and non-viral plant lesions make it difficult to timely diagnose many diseases in plants. The project, carried out in collaboration with the Scientific Center for Biodiversity of Terrestrial Biota of East Asia, Far East Branch of the Russian Academy of Sciences and the Far Eastern Federal University (FEFU), is aimed at developing techniques and methods for mass spectrometric study of plant material to identify the cause of plant pathology. To identify biochemical features that characterize different types of lesions, a multimix approach is used using mass spectrometric profiling and imaging.

Contact Us

E-mail

popov.ia@phystech.edu

Bio Building of MIPT

Dolgoprudny, Institutsky lane, 9c7, room 303, 304