PhD in biology

Scientific supervisor

Valentin Manuvera

Main place of work:

Federal Scientific and Clinical Center for Physical and Chemical Medicine of the Federal Medical and Biological Agency

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Professional interests/research projects:

Genetic engineering, obtaining recombinant proteins.
Main publications:
1.Babenko VV, Podgorny OV, Manuvera VA, Kasianov AS, Manolov AI, Grafskaia EN, Shirokov DA, Kurdyumov AS, Vinogradov DV, Nikitina AS, Kovalchuk SI, Anikanov NA, Butenko IO, Pobeguts OV, Matyushkina DS, Rakitina DV, Kostryukova ES, Zgoda VG, Baskova IP, Trukhan VM, Gelfand MS, Govorun VM, Schiöth HB, Lazarev VN. Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches. BMC Genomics. 2020 Apr 29;21(1):331. doi: 10.1186/s12864-020-6748-0. Erratum in: BMC Genomics. 2020 Jul 22;21(1):503. PMID: 32349672; PMCID: PMC7191736.

2.Shirokov DA, Manuvera VA, Miroshina OA, Dubovoi AS, Samuseva GN, Dmitrieva ME, Lazarev VN. Generation of recombinant VP3 protein of infectious bursal disease virus in three different expression systems, antigenic analysis of the obtained polypeptides and development of an ELISA test. Arch Virol. 2020 Jul;165(7):1611-1620. doi: 10.1007/s00705-020-04650-2. Epub 2020 May 13. PMID: 32405826.

3.Baskova IP, Kalabushev SN, Akhaev DN, Bobrovsky PA, Manuvera VA, Lazarev VN. Role of isopeptidolysis in the process of thrombolysis. Thromb Res. 2018 May;165:18-23. doi: 10.1016/j.thromres.2018.03.007. Epub 2018 Mar 12. PMID: 29549778.

4.Babenko VV, Mikov AN, Manuvera VA, Anikanov NA, Kovalchuk SI, Andreev YA, Logashina YA, Kornilov DA, Manolov AI, Sanamyan NP, Sanamyan KE, Kostryukova ES, Kozlov SA, Grishin EV, Govorun VM, Lazarev VN. Identification of unusual peptides with new Cys frameworks in the venom of the cold-water sea anemone Cnidopus japonicus. Sci Rep. 2017 Nov 6;7(1):14534. doi: 10.1038/s41598-017-14961-1. PMID: 29109403; PMCID: PMC5673964.

5.Bobrovsky P, Manuvera V, Polina N, Podgorny O, Prusakov K, Govorun V, Lazarev V. Recombinant Human Peptidoglycan Recognition Proteins Reveal Antichlamydial Activity. Infect Immun. 2016 Jun 23;84(7):2124-2130. doi: 10.1128/IAI.01495-15. PMID: 27160295; PMCID: PMC4936355.

6.Manuvera VA, Kurdyumov AS, Filonova KA, Lazarev VN. Generation of recombinant destabilase-lysozyme from medicinal leeches in three different expression systems. Protein Expr Purif. 2015 Dec;116:50-8. doi: 10.1016/j.pep.2015.08.012. Epub 2015 Aug 12. PMID: 26277552.

7.Kharlampieva D, Manuvera V, Podgorny O, Grafskaia E, Kovalchuk S, Pobeguts O, Altukhov I, Govorun V, Lazarev V. Recombinant fragilysin isoforms cause E-cadherin cleavage of intact cells and do not cleave isolated E-cadherin. Microb Pathog. 2015 Jun-Jul;83-84:47-56. doi: 10.1016/j.micpath.2015.05.003. Epub 2015 May 18. PMID: 25998017.
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