Doctor of Chemistry, Honorary Professor of Moscow Institute of Physics and Technology

Scientific supervisor

Tatyana Ovchinnikova

Main place of work:

Institute of Bioorganic Chemistry. academicians M.M. Shemyakin and Yu.A. Ovchinnikov Russian Academy of Sciences

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Professional interests/research projects:

The rapid spread of antibiotic-resistant pathogens poses an urgent challenge for the scientific community to develop new anti-infective drugs. The main direction of scientific research is the study of molecular factors of the innate immunity system, in particular, protective peptides of animal, plant and bacterial origin. In recent years, these compounds have attracted close attention of researchers as an alternative to traditional antibiotics due to their ability to quickly destroy a wide range of multi-resistant pathogens and a special molecular mechanism of action that prevents the development of resistance in microorganisms. Bioinformatics search in genomic and transcriptome databases for new structural families of antimicrobial peptides (AMPs) and study of the mechanism of their action on bacteria open the way for the creation of new antibiotics. The objectives of the study include obtaining recombinant AMPs, studying their structure, biological properties and molecular mechanism of action, as well as designing their analogues with more pronounced antimicrobial activity and low toxicity against normal human cells. In particular, peptide translation inhibitors are highly effective in suppressing pathogens, and the emergence of bacterial cross-resistance is less likely. The relatively low cytotoxicity of peptide translation inhibitors allows us to consider them as a promising basis for the development of new generation antibiotics. A number of candidate compounds are being studied in animal models of infectious diseases. The interaction between various AMPs and conventional antibiotics in the joint action on bacterial cells is studied, the possibility of forming resistance to AMPs and ways to overcome it are analyzed.
Main publications:
  1. Bolosov IA, Panteleev PV, Sychev SV, Sukhanov SV, Mironov PA, Myshkin MY, Shenkarev ZO, Ovchinnikova TV. Dodecapeptide Cathelicidins of Cetartiodactyla: Structure, Mechanism of Antimicrobial Action, and Synergistic Interaction With Other Cathelicidins. Front Microbiol. 2021 Aug 13;12:725526. doi: 10.3389/fmicb.2021.725526. PMID: 34484167; PMCID: PMC8415029.
  2. Panteleev PV, Tsarev AV, Safronova VN, Reznikova OV, Bolosov IA, Sychev SV, Shenkarev ZO, Ovchinnikova TV. Structure Elucidation and Functional Studies of a Novel β-hairpin Antimicrobial Peptide from the Marine Polychaeta Capitella teleta. Mar Drugs. 2020 Dec 4;18(12):620. doi: 10.3390/md18120620. PMID: 33291782; PMCID: PMC7761999.
  3. Orlov DS, Shamova OV, Eliseev IE, Zharkova MS, Chakchir OB, Antcheva N, Zachariev S, Panteleev PV, Kokryakov VN, Ovchinnikova TV, Tossi A. Redesigning Arenicin-1, an Antimicrobial Peptide from the Marine Polychaeta Arenicola marina, by Strand Rearrangement or Branching, Substitution of Specific Residues, and Backbone Linearization or Cyclization. Mar Drugs. 2019 Jun 23;17(6):376. doi: 10.3390/md17060376. PMID: 31234579; PMCID: PMC6627698.
  4. Emelianova AA, Kuzmin DV, Panteleev PV, Sorokin M, Buzdin AA, Ovchinnikova TV. Anticancer Activity of the Goat Antimicrobial Peptide ChMAP-28. Front Pharmacol. 2018 Dec 21;9:1501. doi: 10.3389/fphar.2018.01501. PMID: 30622471; PMCID: PMC6308165.
  5. Panteleev PV, Bolosov IA, Kalashnikov AÀ, Kokryakov VN, Shamova OV, Emelianova AA, Balandin SV, Ovchinnikova TV. Combined Antibacterial Effects of Goat Cathelicidins With Different Mechanisms of Action. Front Microbiol. 2018 Nov 30;9:2983. doi: 10.3389/fmicb.2018.02983. PMID: 30555455; PMCID: PMC6284057.
  6. Marggraf MB, Panteleev PV, Emelianova AA, Sorokin MI, Bolosov IA, Buzdin AA, Kuzmin DV, Ovchinnikova TV. Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III. Mar Drugs. 2018 Nov 26;16(12):466. doi: 10.3390/md16120466. PMID: 30486233; PMCID: PMC6315362.
  7. Panteleev PV, Tsarev AV, Bolosov IA, Paramonov AS, Marggraf MB, Sychev SV, Shenkarev ZO, Ovchinnikova TV. Novel Antimicrobial Peptides from the Arctic Polychaeta Nicomache minor Provide New Molecular Insight into Biological Role of the BRICHOS Domain. Mar Drugs. 2018 Oct 23;16(11):401. doi: 10.3390/md16110401. PMID: 30360541; PMCID: PMC6265681.

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