Doctor of Biological Sciences
Scientific supervisor
Oleg Panasenko
Main place of work:
Federal Scientific and Practical Center for Physical and Chemical Medicine of the Federal Medical and Biological Agency, Laboratory of Physical and Chemical Methods of Research and Analysis
Write to the mail
Contacts:
o-panas@mail.ru
Professional interests/research projects:
1. Mechanisms of development of oxidative/halogenating stress. Their role in the development of human diseases.
2. Regulation of the activity of the most important enzyme of leukocytes - myeloperoxidase in order to identify the mechanisms of directed synthesis of hypohalic acids in the foci of inflammation and reduce their damaging effect in healthy tissues.
3. The role of myeloperoxidase in the modification of blood lipoproteins and the development of atherosclerosis.
4. Modulation of the functions of blood cells when myeloperoxidase binds to their plasma membrane under the conditions of development of oxidative/halogenating stress and inflammation.
5. The study of the characteristics of halogenating stress in hyperglycemia, the search for ways to regulate and correct it in order to develop an approach to improve the effectiveness of the treatment of inflammatory complications in diabetes mellitus.
6. Study of the interaction of cationic peptides of the medicinal leech with blood components as the first step towards the systemic use of antimicrobial peptides for the treatment of infectious diseases.
2. Regulation of the activity of the most important enzyme of leukocytes - myeloperoxidase in order to identify the mechanisms of directed synthesis of hypohalic acids in the foci of inflammation and reduce their damaging effect in healthy tissues.
3. The role of myeloperoxidase in the modification of blood lipoproteins and the development of atherosclerosis.
4. Modulation of the functions of blood cells when myeloperoxidase binds to their plasma membrane under the conditions of development of oxidative/halogenating stress and inflammation.
5. The study of the characteristics of halogenating stress in hyperglycemia, the search for ways to regulate and correct it in order to develop an approach to improve the effectiveness of the treatment of inflammatory complications in diabetes mellitus.
6. Study of the interaction of cationic peptides of the medicinal leech with blood components as the first step towards the systemic use of antimicrobial peptides for the treatment of infectious diseases.
Main publications:
- Vasilyev VB, Sokolov AV, Kostevich VA, Elizarova AY, Gorbunov NP, Panasenko OM. Binding of lactoferrin to the surface of low-density lipoproteins modified by myeloperoxidase prevents intracellular cholesterol accumulation by human blood monocytes. Biochem Cell Biol. 2021 Feb;99(1):109-116. doi: 10.1139/bcb-2020-0141. Epub 2020 Jun 16. PMID: 32544357.
- Panasenko OM, Torkhovskaya TI, Gorudko IV, Sokolov AV. The Role of Halogenative Stress in Atherogenic Modification of Low-Density Lipoproteins. Biochemistry (Mosc). 2020 Jan;85(Suppl 1):S34-S55. doi: 10.1134/S0006297920140035. PMID: 32087053.
- Shamova EV, Gorudko IV, Grigorieva DV, Sokolov AV, Kokhan AU, Melnikova GB, Yafremau NA, Gusev SA, Sveshnikova AN, Vasilyev VB, Cherenkevich SN, Panasenko OM. The effect of myeloperoxidase isoforms on biophysical properties of red blood cells. Mol Cell Biochem. 2020 Jan;464(1-2):119-130. doi: 10.1007/s11010-019-03654-0. Epub 2019 Nov 21. PMID: 31754972.
- Gorudko IV, Grigorieva DV, Sokolov AV, Shamova EV, Kostevich VA, Kudryavtsev IV, Syromiatnikova ED, Vasilyev VB, Cherenkevich SN, Panasenko OM. Neutrophil activation in response to monomeric myeloperoxidase. Biochem Cell Biol. 2018 Oct;96(5):592-601. doi: 10.1139/bcb-2017-0290. Epub 2018 Mar 27. PMID: 29585927.
- Vakhrusheva TV, Grigorieva DV, Gorudko IV, Sokolov AV, Kostevich VA, Lazarev VN, Vasilyev VB, Cherenkevich SN, Panasenko OM. Enzymatic and bactericidal activity of myeloperoxidase in conditions of halogenative stress. Biochem Cell Biol. 2018 Oct;96(5):580-591. doi: 10.1139/bcb-2017-0292. Epub 2018 Feb 2. PMID: 29394490.
- Sokolov AV, Kostevich VA, Varfolomeeva EY, Grigorieva DV, Gorudko IV, Kozlov SO, Kudryavtsev IV, Mikhalchik EV, Filatov MV, Cherenkevich SN, Panasenko OM, Arnhold J, Vasilyev VB. Capacity of ceruloplasmin to scavenge products of the respiratory burst of neutrophils is not altered by the products of reactions catalyzed by myeloperoxidase. Biochem Cell Biol. 2018 Aug;96(4):457-467. doi: 10.1139/bcb-2017-0277. Epub 2018 Jan 25. PMID: 29370542.
- Gorudko IV, Sokolov AV, Shamova EV, Grigorieva DV, Mironova EV, Kudryavtsev IV, Gusev SA, Gusev AA, Chekanov AV, Vasilyev VB, Cherenkevich SN, Panasenko OM, Timoshenko AV. Binding of human myeloperoxidase to red blood cells: Molecular targets and biophysical consequences at the plasma membrane level. Arch Biochem Biophys. 2016 Feb 1;591:87-97. doi: 10.1016/j.abb.2015.12.007. Epub 2015 Dec 20. PMID: 26714302.
SPIN РИНЦ:
3035-6808
Researcher ID:
93667
Scopus Author ID:
7005651812
ORCID:
0000-0001-5245-2285
H-index
29
General
School
Educational programs
School structure
© 2001-2022 Moscow Institute of Physics and Technology (National Research University)
Social networks
Language version
Site Search