Mikhail Panteleev

The main area of work of our team is the study of the dynamics and regulation of complex biological systems using computer simulation and experimental approaches. Specific areas include the mechanisms of hemostasis, arterial thrombosis, blood coagulation and fibrinolysis, intracellular signaling in platelets and other cells, interactions of the hemostasis system with the immune system, the role of platelets in cancer, mechanisms of action of drugs and the identification of new therapeutic targets in hematology.

1. Ignatova AA, Suntsova EV, Pshonkin AV, Martyanov AA, Ponomarenko EA, Polokhov DM, Fedorova DV, Voronin KA, Kotskaya NN, Trubina NM, Krasilnikova MV, Uzueva SS, Serkova IV, Ovsyannikova GS, Romanova KI, Hachatryan LA, Kalinina II, Matveev VE, Korsantiya MN, Smetanina NS, Evseev DA, Sadovskaya MN, Antonova KS, Khoreva AL, Zharkov PA, Shcherbina A, Sveshnikova AN, Maschan AA, Novichkova GA, Panteleev MA. Platelet function and bleeding at different phases of childhood immune thrombocytopenia. Sci Rep. 2021 Apr 30;11(1):9401. doi: 10.1038/s41598-021-88900-6. PMID: 33931737; PMCID: PMC8087794.
2. Shibeko AM, Chopard B, Hoekstra AG, Panteleev MA. Redistribution of TPA Fluxes in the Presence of PAI-1 Regulates Spatial Thrombolysis. Biophys J. 2020 Aug 4;119(3):638-651. doi: 10.1016/j.bpj.2020.06.020. Epub 2020 Jun 26. PMID: 32653051; PMCID: PMC7399491.
3. French SL, Butov KR, Allaeys I, Canas J, Morad G, Davenport P, Laroche A, Trubina NM, Italiano JE, Moses MA, Sola-Visner M, Boilard E, Panteleev MA, Machlus KR. Platelet-derived extracellular vesicles infiltrate and modify the bone marrow during inflammation. Blood Adv. 2020 Jul 14;4(13):3011-3023. doi: 10.1182/bloodadvances.2020001758. PMID: 32614966; PMCID: PMC7362363.
4. Panteleev MA, Andreeva AA, Lobanov AI. Differential Drug Target Selection in Blood Coagulation: What can we get from Computational Systems Biology Models? Curr Pharm Des. 2020;26(18):2109-2115. doi: 10.2174/1381612826666200406091807. PMID: 32250213.
5. Obydennyi SI, Artemenko EO, Sveshnikova AN, Ignatova AA, Varlamova TV, Gambaryan S, Lomakina GY, Ugarova NN, Kireev II, Ataullakhanov FI, Novichkova GA, Maschan AA, Shcherbina A, Panteleev M. Mechanisms of increased mitochondria-dependent necrosis in Wiskott-Aldrich syndrome platelets. Haematologica. 2020 Apr;105(4):1095-1106. doi: 10.3324/haematol.2018.214460. Epub 2019 Jul 5. PMID: 31278208; PMCID: PMC7109739.
6. Nechipurenko DY, Receveur N, Yakimenko AO, Shepelyuk TO, Yakusheva AA, Kerimov RR, Obydennyy SI, Eckly A, Léon C, Gachet C, Grishchuk EL, Ataullakhanov FI, Mangin PH, Panteleev MA. Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface. Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):37-47. doi: 10.1161/ATVBAHA.118.311390. PMID: 30580561.
7. Kotova YN, Podoplelova NA, Obydennyy SI, Kostanova EA, Ryabykh AA, Demyanova AS, Biriukova MI, Rosenfeld MA, Sokolov AV, Chambost H, Kumskova MA, Ataullakhanov FI, Alessi MC, Panteleev MA. Binding of Coagulation Factor XIII Zymogen to Activated Platelet Subpopulations: Roles of Integrin αIIbβ3 and Fibrinogen. Thromb Haemost. 2019 Jun;119(6):906-915. doi: 10.1055/s-0039-1683912. Epub 2019 Apr 1. PMID: 30934104.