Laboratory of Personalized Chemo- and Radiotherapy

The purpose of laboratory research is to identify biomarkers and oncogene-like drivers for the acquisition of a chemo- and radio-resistant phenotype with signs of stemness and a high tendency to metastasize by human non-small cell lung cancer (NSCLC) and breast cancer (BC) cells.

One of the key tasks is to determine a set of molecular genetic parameters that make it possible to predict the personal risks of an oncological patient in that the existing tumor will be immune to this type of DNA-damaging chemoradiotherapy, will give metastases and / or relapse after a certain time after the treatment. therapy.

About Laboratory

Our Skills


Creation of a bank of transcriptome information

resistant to chemotherapy/radiation therapy

tumors of specific cancer patients.


Creation of a technology for obtaining and a library of cellular

lines with unique combinations of genetic

changes found in the genome of the most resistant

to the therapy of specific tumors

cancer patients based on non-transformed cells


Evaluation of acquisition by non-transformed cells

human ability to form polyploid

giant tumor cells, acquisition of oncogenic

transformation, radioresistance and ability to



Conducting a comparative analysis of capture and

particle encapsulation nano-sensors invasive and highly

migrating subpopulations of metastatic cancers

cells and characteristics of the endocytic pathway in various

subpopulations of cancer cells.


Optimization of irradiation schemes using heavy

charged particles for the therapy of the most resistant

tumors of specific cancer patients.


Development of an algorithm based on artificial

intelligence for personalized forecasting

the risk of developing metastases in each specific


Our Team
  • Margarita Pustovalova
    Head of Laboratory
  • Sergey Leonov
    Deputy Head of Laboratory
  • Elena Marusich
Our Partners
Connect Us
Bio Building of MIPT
Dolgoprudny, Institutsky lane, 9 c7, room 606-608
Educational programs
School structure
© 2001-2022 Moscow Institute of Physics and Technology (National Research University)
Social networks
Language version
Site Search