Laboratory of Personalized Chemo- and Radiotherapy
The purpose of laboratory research is to identify biomarkers and oncogene-like drivers for the acquisition of a chemo- and radio-resistant phenotype with signs of stemness and a high tendency to metastasize by human non-small cell lung cancer (NSCLC) and breast cancer (BC) cells.
One of the key tasks is to determine a set of molecular genetic parameters that make it possible to predict the personal risks of an oncological patient in that the existing tumor will be immune to this type of DNA-damaging chemoradiotherapy, will give metastases and / or relapse after a certain time after the treatment. therapy.
Our Skills
Creation of a bank of transcriptome information
resistant to chemotherapy/radiation therapy
tumors of specific cancer patients.
Creation of a technology for obtaining and a library of cellular
lines with unique combinations of genetic
changes found in the genome of the most resistant
to the therapy of specific tumors
cancer patients based on non-transformed cells
Evaluation of acquisition by non-transformed cells
human ability to form polyploid
giant tumor cells, acquisition of oncogenic
transformation, radioresistance and ability to
repopulation.
Conducting a comparative analysis of capture and
particle encapsulation nano-sensors invasive and highly
migrating subpopulations of metastatic cancers
cells and characteristics of the endocytic pathway in various
subpopulations of cancer cells.
Optimization of irradiation schemes using heavy
charged particles for the therapy of the most resistant
tumors of specific cancer patients.
Development of an algorithm based on artificial
intelligence for personalized forecasting
the risk of developing metastases in each specific
patient.
- Margarita PustovalovaHead of Laboratory
- Sergey LeonovDeputy Head of Laboratory
- Elena Marusich
