PhD in Biology

Scientific supervisor

Margarita Pustovalova

Main place of work:

MIPT, Laboratory for the Development of Innovative Medicines and Agrobiotechnologies

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Professional interests/research projects:

Study of early and long-term effects of exposure to ionizing radiation (IR) at low doses in human mesenchymal stem cells (MSCs). Features of the formation and repair of DNA double-strand breaks in mammalian cells after exposure to IR. Radioresistance of tumor stem cells of non-small cell lung cancer.
Main publications:
  1. Alhaddad L, Pustovalova M, Blokhina T, Chuprov-Netochin R, Osipov AN, Leonov S. IR-Surviving NSCLC Cells Exhibit Different Patterns of Molecular and Cellular Reactions Relating to the Multifraction Irradiation Regimen and p53-Family Proteins Expression. Cancers (Basel). 2021 May 28;13(11):2669. doi: 10.3390/cancers13112669. PMID: 34071477; PMCID: PMC8198560.
  2. Pustovalova M, Alhaddad L, Blokhina T, Smetanina N, Chigasova A, Chuprov-Netochin R, Eremin P, Gilmutdinova I, Osipov AN, Leonov S. The CD44high Subpopulation of Multifraction Irradiation-Surviving NSCLC Cells Exhibits Partial EMT-Program Activation and DNA Damage Response Depending on Their p53 Status. Int J Mol Sci. 2021 Feb 27;22(5):2369. doi: 10.3390/ijms22052369. PMID: 33673439; PMCID: PMC7956695.
  3. Pustovalova M, Alhaddad L, Smetanina N, Chigasova A, Blokhina T, Chuprov-Netochin R, Osipov AN, Leonov S. The p53-53BP1-Related Survival of A549 and H1299 Human Lung Cancer Cells after Multifractionated Radiotherapy Demonstrated Different Response to Additional Acute X-ray Exposure. Int J Mol Sci. 2020 May 8;21(9):3342. doi: 10.3390/ijms21093342. PMID: 32397297; PMCID: PMC7246764.
  4. Babayan N, Vorobyeva N, Grigoryan B, Grekhova A, Pustovalova M, Rodneva S, Fedotov Y, Tsakanova G, Aroutiounian R, Osipov A. Low Repair Capacity of DNA Double-Strand Breaks Induced by Laser-Driven Ultrashort Electron Beams in Cancer Cells. Int J Mol Sci. 2020 Dec 14;21(24):9488. doi: 10.3390/ijms21249488. PMID: 33327380; PMCID: PMC7764904.
  5. Babayan N, Grigoryan B, Khondkaryan L, Tadevosyan G, Sarkisyan N, Grigoryan R, Apresyan L, Aroutiounian R, Vorobyeva N, Pustovalova M, Grekhova A, Osipov AN. Laser-Driven Ultrashort Pulsed Electron Beam Radiation at Doses of 0.5 and 1.0 Gy Induces Apoptosis in Human Fibroblasts. Int J Mol Sci. 2019 Oct 17;20(20):5140. doi: 10.3390/ijms20205140. PMID: 31627284; PMCID: PMC6829387.
  6. Zorin V, Grekhova A, Pustovalova M, Zorina A, Smetanina N, Vorobyeva N, Kopnin P, Gilmutdinova I, Moskalev A, Osipov AN, Leonov S. Spontaneous γH2AX foci in human dermal fibroblasts in relation to proliferation activity and aging. Aging (Albany NY). 2019 Jul 9;11(13):4536-4546. doi: 10.18632/aging.102067. PMID: 31289256; PMCID: PMC6660037.
  7. Ulyanenko S, Pustovalova M, Koryakin S, Beketov E, Lychagin A, Ulyanenko L, Kaprin A, Grekhova A, M Ozerova A, V Ozerov I, Vorobyeva N, Shegay P, Ivanov S, Leonov S, Klokov D, Osipov AN. Formation of γH2AX and pATM Foci in Human Mesenchymal Stem Cells Exposed to Low Dose-Rate Gamma-Radiation. Int J Mol Sci. 2019 May 29;20(11):2645. doi: 10.3390/ijms20112645. PMID: 31146367; PMCID: PMC6600277.

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