Doctor of Biological Sciences

Scientific supervisor

Alexey Semyanov

Main place of work:

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

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Professional interests/research projects:

Study of intercellular interactions in the central nervous system as the basis of brain functions (learning, memory) and pathological processes (epilepsy, Alzheimer's disease).
Main publications:
1) Alexey Semyanov & Alexei Verkhratsky Astrocytic processes: from tripartite synapses to the active milieu / Trends in Neurosciences 2021 V.44(10), P781-792 doi: 10.1016/j.tins.2021.07.006

2) Alexander Popov, Alexey Brazhe, Pavel Denisov, Oksana Sutyagina, Li Li, Natalia Lazareva, Alexei Verkhratsky, Alexey Semyanov Astrocytes dystrophy in ageing brain parallels impaired synaptic plasticity. Aging Cell,2021, 20: e13334. doi:10.1111/acel.13334

3) Alexey Semyanov, Christian Henneberger, and Amit Agarwal Making sense of astrocytic calcium signals — from acquisition to interpretation / Nature Reviews Neurosci 21, 551–564 2020, doi: 10.1038/s41583-020-0361-8

4) Yulia Dembitskaya, Yu-Wei Wu, Alexey Semyanov Tonic GABAA conductance favors spike-timing-dependent over theta-burst-induced long-term potentiation in the hippocampus / J.Neurosci 2020, 40(22):4266–4276. doi: 10.1523/JNEUROSCI.2118-19.2020

5) Yu-Wei Wu, Susan Gordleeva, Xiaofang Tang, Pie-Yu Shih, Yulia Dembitskaya, Alexey Semyanov Morphological profile determines the frequency of spontaneous calcium events in thin astrocytic processes / Glia 2019, 67:246–262. doi:10.1002/glia.23537

6) Ivan Pavlov, Leonid P. Savtchenko, Inseon Song, Jaeyeon Koo, Alexey Pimashkin, Dmitri A. Rusakov, Alexey Semyanov Tonic GABAA Conductance Bidirectionally Controls Interneuron Firing Pattern and Synchronization in the CA3 Hippocampal Network / Proc Natl Acad Sci USA. 2014 Jan 7;111(1):504-9. doi:10.1073/pnas.1308388110
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