PhD in Chemistry

Scientific supervisor

Alexandr Vassilevski

Main place of work:

IBCh RAS, Laboratory of Molecular Instruments for Neurobiology

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Professional interests/research projects:

Interests lie in neuroscience and the structure and function of proteins. The work of the laboratory is aimed at searching for new modulators of ion channels and neuroreceptors and their use as research tools in neurobiology and as the basis for creating drugs. The search area is focused on animal venoms, which are an invaluable source of such molecules.
Currently, the laboratory is engaged in three main projects: (1) the development of a new analgesic that specifically affects pain receptors; (2) creation of subtype-selective ligands for potassium and sodium channels to elucidate their function; (3) obtaining fluorescent probes based on such ligands for the purpose of mapping ion channels in the nervous system.
Main publications:
  1. Mineev KS, Kuzmenkov AI, Arseniev AS, Vassilevski AA. Structure of MeuNaTxα-1 toxin from scorpion venom highlights the importance of the nest motif. Proteins. 2021 Mar 13. doi: 10.1002/prot.26074. Epub ahead of print. PMID: 33713480.
  2. Tabakmakher VM, Krylov NA, Kuzmenkov AI, Efremov RG, Vassilevski AA. Kalium 2.0, a comprehensive database of polypeptide ligands of potassium channels. Sci Data. 2019 May 27;6(1):73. doi: 10.1038/s41597-019-0074-x. PMID: 31133708; PMCID: PMC6536513.
  3. Twomey EC, Yelshanskaya MV, Vassilevski AA, Sobolevsky AI. Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron. 2018 Sep 5;99(5):956-968.e4. doi: 10.1016/j.neuron.2018.07.027. Epub 2018 Aug 16. PMID: 30122377; PMCID: PMC6181147.
  4. Männikkö R, Shenkarev ZO, Thor MG, Berkut AA, Myshkin MY, Paramonov AS, Kulbatskii DS, Kuzmin DA, Sampedro Castañeda M, King L, Wilson ER, Lyukmanova EN, Kirpichnikov MP, Schorge S, Bosmans F, Hanna MG, Kullmann DM, Vassilevski AA. Spider toxin inhibits gating pore currents underlying periodic paralysis. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4495-4500. doi: 10.1073/pnas.1720185115. Epub 2018 Apr 10. PMID: 29636418; PMCID: PMC5924911.
  5. Berkut AA, Usmanova DR, Peigneur S, Oparin PB, Mineev KS, Odintsova TI, Tytgat J, Arseniev AS, Grishin EV, Vassilevski AA. Structural similarity between defense peptide from wheat and scorpion neurotoxin permits rational functional design. J Biol Chem. 2014 May 16;289(20):14331-40. doi: 10.1074/jbc.M113.530477. Epub 2014 Mar 26. PMID: 24671422; PMCID: PMC4022899.
  6. Vassilevski AA, Fedorova IM, Maleeva EE, Korolkova YV, Efimova SS, Samsonova OV, Schagina LV, Feofanov AV, Magazanik LG, Grishin EV. Novel class of spider toxin: active principle from the yellow sac spider Cheiracanthium punctorium venom is a unique two-domain polypeptide. J Biol Chem. 2010 Oct 15;285(42):32293-302. doi: 10.1074/jbc.M110.104265. Epub 2010 Jul 24. PMID: 20657014; PMCID: PMC2952230.
  7. Grishin EV, Savchenko GA, Vassilevski AA, Korolkova YV, Boychuk YA, Viatchenko-Karpinski VY, Nadezhdin KD, Arseniev AS, Pluzhnikov KA, Kulyk VB, Voitenko NV, Krishtal OO. Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain. Ann Neurol. 2010 May;67(5):680-3. doi: 10.1002/ana.21949. PMID: 20437566.
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