Candidate of Physical and Mathematical Sciences

Scientific supervisor

Anton Zalygin

Main place of work:

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

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Professional interests/research projects:

Anton Vladlenovich is developing methods and instruments for biomedical research.
One of the directions is based on the use of a combination of atomic force microscopy (AFM) and Raman spectroscopy (Raman spectroscopy) and giant Raman scattering (TERS, SERS) to study the interaction of metal and semiconductor nanoparticles with biological, chemical and medical objects. In particular, studies are being conducted on the influence of malignant tumors and other life-threatening factors, both in vitro and in vivo.
In addition, approaches are used in the framework of which, for a deeper study of the ultrastructure, physical and chemical properties of nanomaterials and their complexes, complementary methods are used, for example, scanning probe spectroscopy and optical microspectroscopy for multiparametric analysis. This approach is used, for example, for complex characterization of the association of molecules of various Function-spacer-lipid constructs under physiological conditions.
To experimentally determine the internal structure of nanoparticles, the small-angle X-ray scattering (SAXS) method is used, while more detailed data on the internal structure and surface properties of nanoparticles and their functional parts in dynamics are obtained using the molecular dynamics (MD) method.
Main publications:
1. Zalygin A, Solovyeva D, Vaskan I, Henry S, Schaefer M, Volynsky P, Tuzikov A, Korchagina E, Ryzhov I, Nizovtsev A, Mochalov K, Efremov R, Shtykova E, Oleinikov V, Bovin N. Structure of Supramers Formed by the Amphiphile Biotin-CMG-DOPE. ChemistryOpen. 2020 Apr 6;9(6):641-648. doi: 10.1002/open.201900276. PMID: 32499990; PMCID: PMC7266497.
2. Mochalov KE, Chistyakov AA, Solovyeva DO, Mezin AV, Oleinikov VA, Vaskan IS, Molinari M, Agapov II, Nabiev I, Efimov AE. An instrumental approach to combining confocal microspectroscopy and 3D scanning probe nanotomography. Ultramicroscopy. 2017 Nov;182:118-123. doi: 10.1016/j.ultramic.2017.06.022. Epub 2017 Jun 21. PMID: 28672183.
3. Oleinikov, V.A., Lukashev, E.P., Zaitsev, S.Y. et al. The effect of plasmon silver and exiton semiconductor nanoparticles on the bacteriorhodopsin photocycle in Halobacterium salinarum membranes. Opt. Spectrosc. 122, 30–35 (2017).
4. Konstantin Mochalov, Daria Solovyeva, Anton Chistyakov, Boris Zimka, Eugeni Lukashev, Igor Nabiev, Vladimir Oleinikov, Silver Nanoparticles Strongly Affect the Properties of Bacteriorhodopsin, a Photosensitive Protein of Halobacterium Salinarium Purple Membranes, Materials Today: Proceedings, Volume 3, Issue 2, 2016, Pages 502-506, ISSN 2214-7853,
5. Konstantin Mochalov, Daria Solovyeva, Anton Chistyakov, Boris Zimka, Eugeni Lukashev, Igor Nabiev, Vladimir Oleinikov, Raman and SERS Spectroscopy of D96N Mutant Bacteriorhodopsin, Materials Today: Proceedings, Volume 3, Issue 2, 2016, Pages 497-501,
ISSN 2214-7853,
6. Oleinikov, V.A., Mochalov, K.E., Solovyeva, D.O. et al. The effect of silver nanoparticles on the photocycle of bacteriorhodopsin of purple membranes of Halobacterium salinarum . Opt. Spectrosc. 121, 210–219 (2016).
7. Мочалов К.Е., Олейников В.А., Залыгин А.В., Соловьева Д.О. (2018) Спектрометр комбинационного рассеяния с совмещением микро- и макрорежимов для химического и структурного анализа веществ // Патент России № 2672792
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